PMID- 27416564
OWN - NLM
STAT- MEDLINE
DCOM- 20170424
LR  - 20171213
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 139
IP  - 10
DP  - 2016 Nov 15
TI  - Early onset pancreatic malignancies: Clinical characteristics and survival 
      associations.
PG  - 2169-77
LID - 10.1002/ijc.30273 [doi]
AB  - Diagnosed before age 50, early onset pancreatic malignancy (EOPM), is 
      hypothesized to be a distinct subset of disease, although research is limited. To 
      better characterize EOPM, and the effect of age at diagnosis on pancreatic cancer 
      survival, we examined clinical characteristics and survival in EOPM and typical 
      age-at-onset pancreatic malignancy (TOPM) cases. Vanderbilt University Medical 
      Center (VUMC) Cancer Registry confirmed pancreatic adenocarcinomas (PDACs) and 
      malignant pancreatic neuroendocrine tumors (PNETs) were evaluated. Clinical 
      characteristics were compared using chi(2) tests. Overall survival was visualized 
      with Kaplan-Meier functions; Cox proportional hazards regression was used to 
      evaluate hazard ratios (HRs) and 95% confidence intervals (CIs). A total of 1,697 
      pancreatic malignancies were diagnosed at the VUMC between 1988 and 2013. Of 
      1,407 PDACs, 118 (8.4%) were EOPM, which was associated with significantly better 
      survival (adjusted HR: 0.82, 95% CI: 0.67-1.00). EOPM and TOPM PDACs 
      significantly differed with regard to having multiple malignancies; survival 
      associations significantly differed by race, stage of disease, treatment and 
      multiple malignancies. Of 190 PNETs, 63 (33.1%) were EOPM, which was not 
      significantly associated with survival (adjusted HR: 0.80, 95% CI: 0.46-1.40). 
      Malignant neuroendocrine EOPM and TOPM cases significantly differed by stage of 
      disease and tumor location; survival associations significantly differed by 
      family history of pancreatic cancer, stage of disease and multiple malignancies. 
      Differences in clinical characteristics and associations with survival were 
      identified, indicating that EOPM is distinct from TOPM, and exists among both 
      pancreatic adenocarcinomas and malignant pancreatic neuroendocrine tumors.
CI  - (c) 2016 UICC.
FAU - Beeghly-Fadiel, Alicia
AU  - Beeghly-Fadiel A
AD  - Division of Epidemiology, School of Medicine, Vanderbilt University Medical 
      Center and Vanderbilt Ingram Comprehensive Cancer Center, Nashville, TN.
FAU - Luu, Hung N
AU  - Luu HN
AD  - Division of Epidemiology, School of Medicine, Vanderbilt University Medical 
      Center and Vanderbilt Ingram Comprehensive Cancer Center, Nashville, TN.
AD  - Department of Epidemiology and Biostatistics, College of Public Health, 
      University of South Florida, Tampa, FL.
FAU - Du, Liping
AU  - Du L
AD  - School of Medicine, Center for Quantitative Sciences, Vanderbilt University 
      Medical Center and Vanderbilt Ingram Comprehensive Cancer Center, Nashville, TN.
FAU - Shi, Chanjuan
AU  - Shi C
AD  - Department of Pathology, School of Medicine, Vanderbilt University Medical 
      Center, Nashville, TN.
FAU - McGavic, Dauphne P
AU  - McGavic DP
AD  - Vanderbilt Cancer Registry, Vanderbilt University Medical Center and Vanderbilt 
      Ingram Comprehensive Cancer Center, Nashville, TN.
FAU - Parikh, Alexander A
AU  - Parikh AA
AD  - Division of Surgical Oncology and Endocrine Surgery, School of Medicine, 
      Vanderbilt University Medical Center, Nashville, TN.
FAU - Raskin, Leon
AU  - Raskin L
AD  - Division of Epidemiology, School of Medicine, Vanderbilt University Medical 
      Center and Vanderbilt Ingram Comprehensive Cancer Center, Nashville, TN. 
      leonid.raskin@vanderbilt.edu.
LA  - eng
PT  - Journal Article
DEP - 20160822
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
SB  - IM
MH  - Adenocarcinoma/epidemiology/mortality/pathology
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Pancreatic Ductal/epidemiology/mortality/pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Neuroendocrine Tumors/epidemiology/mortality/pathology
MH  - Pancreatic Neoplasms/*epidemiology/mortality/pathology
MH  - United States/epidemiology
OTO - NOTNLM
OT  - PDAC
OT  - PNET
OT  - early onset
OT  - pancreatic cancer
OT  - survival
EDAT- 2016/07/15 06:00
MHDA- 2017/04/25 06:00
CRDT- 2016/07/15 06:00
PHST- 2016/02/24 00:00 [received]
PHST- 2016/06/08 00:00 [revised]
PHST- 2016/07/05 00:00 [accepted]
PHST- 2016/07/15 06:00 [entrez]
PHST- 2016/07/15 06:00 [pubmed]
PHST- 2017/04/25 06:00 [medline]
AID - 10.1002/ijc.30273 [doi]
PST - ppublish
SO  - Int J Cancer. 2016 Nov 15;139(10):2169-77. doi: 10.1002/ijc.30273. Epub 2016 Aug 
      22.