PMID- 27416692
OWN - NLM
STAT- MEDLINE
DCOM- 20160728
LR  - 20160715
IS  - 1066-2936 (Print)
IS  - 1066-2936 (Linking)
VI  - 43
IP  - 3
DP  - 2016 May-Jun
TI  - Renin-angiotensin system and its role in hyperoxic acute lung injury.
PG  - 239-46
AB  - Oxygen is essential to sustain life, but at a high partial pressure oxygen may 
      cause toxicity to the human body. These injuries to the lung are known as 
      hyperoxic acute lung injury [HALI]). To date, numerous studies have been 
      conducted to investigate the pathogenesis of HALI, for which some hypotheses have 
      been proposed. Accumulating evidence indicates that the renin-angiotensin system 
      (RAS) plays an important role in the pathogenesis of some lung diseases, 
      including acute lung injury (ALI), chronic obstructive pulmonary disease (COPD) 
      and HALI. In this review, we briefly introduce the classic RAS, local (tissue) 
      RAS and intracellular RAS, and we summarize findings on the relationship between 
      local/classic RAS and HALI. The importance--and ambiguity--of the results of 
      these studies indicate a need for further investigations of the RAS and its role 
      in the patho- genesis of HALI.
FAU - Zhang, P X
AU  - Zhang PX
FAU - Han, C H
AU  - Han CH
FAU - Zhou, F J
AU  - Zhou FJ
FAU - Li, L
AU  - Li L
FAU - Zhang, H M
AU  - Zhang HM
FAU - Liu, W W
AU  - Liu WW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Undersea Hyperb Med
JT  - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical 
      Society, Inc
JID - 9312954
SB  - IM
MH  - Acute Lung Injury/*etiology
MH  - Humans
MH  - Hyperoxia/*complications
MH  - Hypertension, Pulmonary/etiology
MH  - Lung/metabolism
MH  - Pulmonary Disease, Chronic Obstructive/etiology
MH  - Renin-Angiotensin System/*physiology
EDAT- 2016/07/16 06:00
MHDA- 2016/07/29 06:00
CRDT- 2016/07/16 06:00
PHST- 2016/07/16 06:00 [entrez]
PHST- 2016/07/16 06:00 [pubmed]
PHST- 2016/07/29 06:00 [medline]
PST - ppublish
SO  - Undersea Hyperb Med. 2016 May-Jun;43(3):239-46.