PMID- 27417010 OWN - NLM STAT- MEDLINE DCOM- 20170630 LR - 20180920 IS - 1558-3597 (Electronic) IS - 0735-1097 (Linking) VI - 68 IP - 3 DP - 2016 Jul 19 TI - Management of Patients With NSTE-ACS: A Comparison of the Recent AHA/ACC and ESC Guidelines. PG - 313-321 LID - S0735-1097(16)33129-1 [pii] LID - 10.1016/j.jacc.2016.03.599 [doi] AB - Non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are the leading cause of morbidity and mortality from cardiovascular disease worldwide. The American Heart Association/American College of Cardiology and the European Society of Cardiology periodically release practice guidelines to guide clinicians in the management of NSTE-ACS, most recently in in 2014 and 2015, respectively. The present review compares and contrasts the 2 guidelines, with a focus on the strength of recommendation and level of evidence in the approach to initial presentation and diagnosis of NSTE-ACS, risk assessment, treatments, and systems of care. Important differences include the use of a rapid rule-out protocol with high-sensitivity troponin assays, a preference for prasugrel/ticagrelor and fondaparinux for anticoagulation therapy, and a preference for radial arterial access in the European Society of Cardiology guidelines compared with the American Heart Association/American College of Cardiology guidelines. We also highlight the similarities and differences in the guidelines for special patient populations and suggest areas of further study. CI - Copyright (c) 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. FAU - Rodriguez, Fatima AU - Rodriguez F AD - Stanford University School of Medicine, Department of Medicine, Division of Cardiovascular Medicine, Stanford, California. FAU - Mahaffey, Kenneth W AU - Mahaffey KW AD - Stanford University School of Medicine, Department of Medicine, Division of Cardiovascular Medicine, Stanford, California. Electronic address: kenneth.mahaffey@stanford.edu. LA - eng PT - Journal Article PT - Review PL - United States TA - J Am Coll Cardiol JT - Journal of the American College of Cardiology JID - 8301365 RN - 0 (Anticoagulants) RN - 0 (Platelet Aggregation Inhibitors) SB - IM MH - Acute Coronary Syndrome/*therapy MH - Anticoagulants/*therapeutic use MH - Cardiology/*methods MH - *Electrocardiography MH - Europe MH - Platelet Aggregation Inhibitors/*therapeutic use MH - *Practice Guidelines as Topic MH - *Societies, Medical MH - United States OTO - NOTNLM OT - acute coronary syndrome OT - anticoagulants OT - antiplatelet OT - quality of care OT - risk assessment EDAT- 2016/07/16 06:00 MHDA- 2017/07/01 06:00 CRDT- 2016/07/16 06:00 PHST- 2015/12/10 00:00 [received] PHST- 2016/02/25 00:00 [revised] PHST- 2016/03/01 00:00 [accepted] PHST- 2016/07/16 06:00 [entrez] PHST- 2016/07/16 06:00 [pubmed] PHST- 2017/07/01 06:00 [medline] AID - S0735-1097(16)33129-1 [pii] AID - 10.1016/j.jacc.2016.03.599 [doi] PST - ppublish SO - J Am Coll Cardiol. 2016 Jul 19;68(3):313-321. doi: 10.1016/j.jacc.2016.03.599.