PMID- 27417525
OWN - NLM
STAT- MEDLINE
DCOM- 20170523
LR  - 20180103
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Linking)
VI  - 306
DP  - 2016 Sep 1
TI  - Cadmium-induced neural tube defects and fetal growth restriction: Association 
      with disturbance of placental folate transport.
PG  - 79-85
LID - S0041-008X(16)30181-8 [pii]
LID - 10.1016/j.taap.2016.07.007 [doi]
AB  - Previous studies found that maternal Cd exposure on gestational day (GD)9 caused 
      forelimb ectrodactyly and tail deformity, the characteristic malformations. The 
      aim of the present study was to investigate whether maternal Cd exposure on GD8 
      induces fetal neural tube defects (NTDs). Pregnant mice were intraperitoneally 
      injected with CdCl2 (2.5 or 5.0mg/kg) on GD8. Neither forelimb ectrodactyly nor 
      tail deformity was observed in mice injected with CdCl2 on GD8. Instead, maternal 
      Cd exposure on GD8 resulted in the incidence of NTDs. Moreover, maternal Cd 
      exposure on GD8 resulted in fetal growth restriction. In addition, maternal Cd 
      exposure on GD8 reduced placental weight and diameter. The internal space of 
      maternal and fetal blood vessels in the labyrinth layer was decreased in the 
      placentas of mice treated with CdCl2. Additional experiment showed that placental 
      PCFT protein and mRNA, a critical folate transporter, was persistently decreased 
      when dams were injected with CdCl2 on GD8. Correspondingly, embryonic folate 
      content was markedly decreased in mice injected with CdCl2 on GD8, whereas Cd had 
      little effect on folate content in maternal serum. Taken together, these results 
      suggest that maternal Cd exposure during organogenesis disturbs transport of 
      folate from maternal circulation to the fetuses through down-regulating placental 
      folate transporters.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Zhang, Gui-Bin
AU  - Zhang GB
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, PR China.
FAU - Wang, Hua
AU  - Wang H
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, PR China. Electronic address: wanghuadev@126.com.
FAU - Hu, Jun
AU  - Hu J
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, PR China.
FAU - Guo, Min-Yin
AU  - Guo MY
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, PR China.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, PR China.
FAU - Zhou, Yan
AU  - Zhou Y
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, PR China.
FAU - Yu, Zhen
AU  - Yu Z
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, PR China.
FAU - Fu, Lin
AU  - Fu L
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, PR China.
FAU - Chen, Yuan-Hua
AU  - Chen YH
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, PR China.
FAU - Xu, De-Xiang
AU  - Xu DX
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, PR China. Electronic address: xudex@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160711
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Proton-Coupled Folate Transporter)
RN  - 0 (RNA, Messenger)
RN  - 00BH33GNGH (Cadmium)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Animals
MH  - Cadmium/*toxicity
MH  - Down-Regulation
MH  - Embryo, Mammalian/metabolism
MH  - Female
MH  - Fetal Growth Retardation/*chemically induced
MH  - Folic Acid/blood/*metabolism
MH  - Maternal-Fetal Exchange
MH  - Mice, Inbred ICR
MH  - Neural Tube Defects/*chemically induced
MH  - Placenta/*drug effects/metabolism
MH  - Placentation/drug effects
MH  - Pregnancy
MH  - Proton-Coupled Folate Transporter/genetics
MH  - RNA, Messenger/metabolism
OTO - NOTNLM
OT  - Cadmium
OT  - Fetal growth restriction
OT  - Folate
OT  - Neural tube defects
OT  - Placenta
OT  - Proton-coupled folate transporter
EDAT- 2016/07/16 06:00
MHDA- 2017/05/24 06:00
CRDT- 2016/07/16 06:00
PHST- 2016/04/30 00:00 [received]
PHST- 2016/06/30 00:00 [revised]
PHST- 2016/07/08 00:00 [accepted]
PHST- 2016/07/16 06:00 [entrez]
PHST- 2016/07/16 06:00 [pubmed]
PHST- 2017/05/24 06:00 [medline]
AID - S0041-008X(16)30181-8 [pii]
AID - 10.1016/j.taap.2016.07.007 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2016 Sep 1;306:79-85. doi: 10.1016/j.taap.2016.07.007. 
      Epub 2016 Jul 11.