PMID- 27417763
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160715
LR  - 20220331
IS  - 2227-9032 (Print)
IS  - 2227-9032 (Electronic)
IS  - 2227-9032 (Linking)
VI  - 3
IP  - 2
DP  - 2015 May 21
TI  - Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus.
PG  - 296-309
LID - 10.3390/healthcare3020296 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a major cause of morbidity and mortality with 
      ever increasing prevalence in the United States and worldwide. There is growing 
      body of evidence suggesting that mitochondrial dysfunction secondary to oxidative 
      stress plays a critical role in the pathogenesis of T2DM. Coenzyme Q10 is an 
      important micronutrient acting on the electron transport chain of the 
      mitochondria with two major functions: (1) synthesis of adenosine triphosphate 
      (ATP); and (2) a potent antioxidant. Deficiency in coenzyme Q10 is often seen in 
      patients with T2DM. Whether restoration of coenzyme Q10 will help alleviate 
      oxidative stress, preserve mitochondrial function, and thus improve glycemic 
      control in T2DM is unclear. This article reviews the relationships among 
      oxidative stress, mitochondrial dysfunction, and T2DM and examines the evidence 
      for potential use of coenzyme Q10 as a supplement for the treatment of T2DM.
FAU - Shen, Qiuhua
AU  - Shen Q
AD  - School of Nursing, University of Kansas, 3901 Rainbow Blvd., Mailstop 4043, 
      Kansas City, KS 66160, USA. qshen@kumc.edu.
FAU - Pierce, Janet D
AU  - Pierce JD
AD  - School of Nursing, University of Kansas, 3901 Rainbow Blvd., Mailstop 4043, 
      Kansas City, KS 66160, USA. jpierce@kumc.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150521
PL  - Switzerland
TA  - Healthcare (Basel)
JT  - Healthcare (Basel, Switzerland)
JID - 101666525
PMC - PMC4939545
OTO - NOTNLM
OT  - adenosine triphosphate
OT  - antioxidant
OT  - coenzyme Q10
OT  - mitochondrial dysfunction
OT  - oxidative stress
OT  - type 2 diabetes mellitus
EDAT- 2015/01/01 00:00
MHDA- 2015/01/01 00:01
PMCR- 2015/05/21
CRDT- 2016/07/16 06:00
PHST- 2015/03/03 00:00 [received]
PHST- 2015/04/20 00:00 [revised]
PHST- 2015/05/14 00:00 [accepted]
PHST- 2016/07/16 06:00 [entrez]
PHST- 2015/01/01 00:00 [pubmed]
PHST- 2015/01/01 00:01 [medline]
PHST- 2015/05/21 00:00 [pmc-release]
AID - healthcare3020296 [pii]
AID - healthcare-03-00296 [pii]
AID - 10.3390/healthcare3020296 [doi]
PST - epublish
SO  - Healthcare (Basel). 2015 May 21;3(2):296-309. doi: 10.3390/healthcare3020296.