PMID- 27418150
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20181104
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 45
IP  - 2
DP  - 2017 Feb
TI  - Assessment of infarct-specific cardiac motion dysfunction using modeling and 
      multimodal magnetic resonance merging.
PG  - 525-534
LID - 10.1002/jmri.25390 [doi]
AB  - PURPOSE: To propose a cardiac motion tracking model that evaluates wall motion 
      abnormality in postmyocardial infarction patients. Correlation between the motion 
      parameter of the model and left ventricle (LV) function was also determined. 
      MATERIALS AND METHODS: Twelve male patients with post-ST elevation myocardial 
      infarction (post-STEMI) and 10 healthy controls of the same gender were recruited 
      to undergo cardiac magnetic resonance imaging (MRI) using a 1.5T scanner. Using 
      an infarct-specific LV division approach, the late gadolinium enhancement (LGE) 
      MRI images were used to divide the LV on the tagged MRI images into infarct, 
      adjacent, and remote sectors. Motion tracking was performed using the 
      infarct-specific two-parameter empirical deformable model (TPEDM). The match 
      quality was defined as the position error computed using root-mean-square (RMS) 
      distance between the estimated and expert-verified tag intersections. The 
      position errors were compared with the ones from our previously published 
      fixed-sector TPEDM. Cine MRI images were used to calculate regional ejection 
      fraction (REF). Correlation between the end-systolic contraction parameter (alpha(ES) 
      ) with REF was determined. RESULTS: The position errors in the proposed model 
      were significantly lower than the fixed-sector model (P < 0.01). The median 
      position errors were 0.82 mm versus 1.23 mm. The alpha(ES) correlates significantly 
      with REF (r = 0.91, P < 0.01). CONCLUSION: The infarct-specific TPEDM combines 
      the morphological and functional information from LGE and tagged MRI images. It 
      was shown to outperform the fixed-sector model in assessing regional LV 
      dysfunction. The significant correlation between alpha(ES) and REF added prognostic 
      value because it indicated an impairment of cardiac function with the increase of 
      infarct transmurality. LEVEL OF EVIDENCE: 3 J. Magn. Reson. Imaging 
      2017;45:525-534.
CI  - (c) 2016 International Society for Magnetic Resonance in Medicine.
FAU - Leong, Chen Onn
AU  - Leong CO
AD  - Department of Biomedical Engineering, Faculty of Engineering, University of 
      Malaya, Kuala Lumpur, Malaysia.
FAU - Liew, Yih Miin
AU  - Liew YM
AD  - Department of Biomedical Engineering, Faculty of Engineering, University of 
      Malaya, Kuala Lumpur, Malaysia.
FAU - Bilgen, Mehmet
AU  - Bilgen M
AD  - Biophysics Department, Faculty of Medicine, Adnan Menderes University, Aydin, 
      Turkey.
FAU - Abdul Aziz, Yang Faridah
AU  - Abdul Aziz YF
AD  - Department of Biomedical Imaging, University Malaya Research Imaging Centre, 
      Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
FAU - Chee, Kok Han
AU  - Chee KH
AD  - Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, 
      Malaysia.
FAU - Chiam, Yin Kia
AU  - Chiam YK
AD  - Department of Software Engineering, Faculty of Computer Science & Information 
      Technology, University of Malaya, Kuala Lumpur, Malaysia.
FAU - Lim, Einly
AU  - Lim E
AD  - Department of Biomedical Engineering, Faculty of Engineering, University of 
      Malaya, Kuala Lumpur, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160715
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Computer Simulation
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - *Models, Cardiovascular
MH  - Motion
MH  - Movement
MH  - Multimodal Imaging/methods
MH  - Myocardial Infarction/complications/*diagnostic imaging/*physiopathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Subtraction Technique
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/etiology/*physiopathology
OTO - NOTNLM
OT  - LV motion analysis
OT  - cardiac modeling
OT  - late gadolinium enhancement
OT  - myocardial infarction
OT  - tagged MRI
EDAT- 2016/07/16 06:00
MHDA- 2018/02/13 06:00
CRDT- 2016/07/16 06:00
PHST- 2016/04/04 00:00 [received]
PHST- 2016/06/30 00:00 [accepted]
PHST- 2016/07/16 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
PHST- 2016/07/16 06:00 [entrez]
AID - 10.1002/jmri.25390 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2017 Feb;45(2):525-534. doi: 10.1002/jmri.25390. Epub 2016 
      Jul 15.