PMID- 27419057
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160715
LR  - 20181113
IS  - 2211-5463 (Print)
IS  - 2211-5463 (Electronic)
IS  - 2211-5463 (Linking)
VI  - 6
IP  - 6
DP  - 2016 Jun
TI  - TAK1 deficiency in dendritic cells inhibits adaptive immunity in SRBC-immunized 
      C57BL/6 mice.
PG  - 548-57
LID - 10.1002/2211-5463.12062 [doi]
AB  - Dendritic cells (DCs) are important in the initiation of primary T-cell 
      responses, while transforming growth factor-beta (TGF-beta)-activated kinase 1 (TAK1) 
      is a critical regulator of DC survival and homeostasis. This study evaluated the 
      T-cell dependent antibody response (TDAR) to sheep red blood cells (SRBC) on a 
      DC-specific TAK1-deficient mice model. The results showed that TAK1 deficiency in 
      DCs significantly suppressed the humoral and cellular immune response in mice. 
      DC-specific TAK1 deletion impaired splenic T-cell population and conventional 
      DCs, abolished the cytokine production of splenic T cells and down-regulated some 
      functional gene expression in the spleen. Collectively, this study suggests that 
      TAK1 plays an essential role in the development of the humoral immune response.
FAU - Pan, Yao
AU  - Pan Y
AD  - Department of ToxicologySchool of Public HealthPeking UniversityBeijingChina; 
      Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food 
      SafetyBeijingChina.
FAU - Lei, Zhiming
AU  - Lei Z
AD  - Department of ToxicologySchool of Public HealthPeking UniversityBeijingChina; 
      Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food 
      SafetyBeijingChina.
FAU - Wei, Xuetao
AU  - Wei X
AD  - Department of ToxicologySchool of Public HealthPeking UniversityBeijingChina; 
      Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food 
      SafetyBeijingChina.
FAU - Hao, Weidong
AU  - Hao W
AD  - Department of ToxicologySchool of Public HealthPeking UniversityBeijingChina; 
      Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food 
      SafetyBeijingChina.
LA  - eng
PT  - Journal Article
DEP - 20160421
PL  - England
TA  - FEBS Open Bio
JT  - FEBS open bio
JID - 101580716
PMC - PMC4887970
OTO - NOTNLM
OT  - T-cell dependent antigen response
OT  - dendritic cells
OT  - sheep red blood cells
OT  - transforming growth factor-beta-activated kinase 1
EDAT- 2016/07/16 06:00
MHDA- 2016/07/16 06:01
PMCR- 2016/04/21
CRDT- 2016/07/16 06:00
PHST- 2016/01/26 00:00 [received]
PHST- 2016/03/21 00:00 [revised]
PHST- 2016/03/29 00:00 [accepted]
PHST- 2016/07/16 06:00 [entrez]
PHST- 2016/07/16 06:00 [pubmed]
PHST- 2016/07/16 06:01 [medline]
PHST- 2016/04/21 00:00 [pmc-release]
AID - FEB412062 [pii]
AID - 10.1002/2211-5463.12062 [doi]
PST - epublish
SO  - FEBS Open Bio. 2016 Apr 21;6(6):548-57. doi: 10.1002/2211-5463.12062. eCollection 
      2016 Jun.