PMID- 27419833
OWN - NLM
STAT- MEDLINE
DCOM- 20170713
LR  - 20221207
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 30
IP  - 11
DP  - 2016 Nov
TI  - Association of CD59 and CFH polymorphisms with acute anterior uveitis in Chinese 
      population.
PG  - 1452-1457
LID - 10.1038/eye.2016.146 [doi]
AB  - PurposeCD59 complement regulator and complement factor H (CFH) have important 
      roles in complement activation pathways, which are known to affect the 
      development of uveitis. The present study was performed to investigate whether an 
      association exists between CD59 and CFH genetic polymorphisms and acute anterior 
      uveitis (AAU).MethodsA total of 600 individuals (300 patients diagnosed with AAU 
      and 300 healthy controls) were recruited for this case-control study. Five 
      single-nucleotide polymorphisms (SNPs) in CD59 (rs831626, rs12272807, rs831625, 
      rs11585, and rs12576440) and CFH-rs1065489 were genotyped using Sequenom 
      MassARRAY technology. Allele and genotype frequencies were statistically compared 
      between patients and controls using chi(2) test. Analyses were stratified for 
      gender, human leukocyte antigen (HLA)-B27, and ankylosing spondylitis (AS) 
      status.ResultsNo significant association was found between any of the six 
      polymorphisms and AAU. In HLA-B27-negative AAU patients, the frequencies of the G 
      allele and GG homozygosity were lower in CD59-rs831626 when compared with 
      controls (P=0.032). There were also significant decreases in the frequencies of T 
      allele and TT homozygosity in CFH-rs1065489 in AAU patients with AS compared with 
      controls (P=0.002). Furthermore, the frequencies of the T allele and TT 
      homozygosity in CFH-rs1065489 were lower in the AAU male patients with AS 
      compared with controls (P=0.015).ConclusionOur results revealed that SNPs 
      CD59-rs831626 and CFH-rs1065489 were associated with the susceptibility of AAU. 
      The influence on AAU could be gender specific and dependent on the HLA-B27 and AS 
      status. No positive results were found in the overall group.
FAU - Wang, Q F
AU  - Wang QF
AD  - Division of Ophthalmic Genetics, The Eye Hospital of Wenzhou Medical University, 
      State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, 
      Ministry of Health, Wenzhou, China.
FAU - Huang, X F
AU  - Huang XF
AD  - Division of Ophthalmic Genetics, The Eye Hospital of Wenzhou Medical University, 
      State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, 
      Ministry of Health, Wenzhou, China.
FAU - Zheng, Z L
AU  - Zheng ZL
AD  - Division of Ophthalmic Genetics, The Eye Hospital of Wenzhou Medical University, 
      State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, 
      Ministry of Health, Wenzhou, China.
FAU - Dai, M L
AU  - Dai ML
AD  - Division of Ophthalmic Genetics, The Eye Hospital of Wenzhou Medical University, 
      State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, 
      Ministry of Health, Wenzhou, China.
FAU - Cai, W J
AU  - Cai WJ
AD  - Division of Ophthalmic Genetics, The Eye Hospital of Wenzhou Medical University, 
      State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, 
      Ministry of Health, Wenzhou, China.
FAU - Yang, M M
AU  - Yang MM
AD  - Department of Ophthalmology, Eye Hospital, The First Affiliated Hospital, Harbin 
      Medical University, Harbin, China.
FAU - Jin, Z B
AU  - Jin ZB
AD  - Division of Ophthalmic Genetics, The Eye Hospital of Wenzhou Medical University, 
      State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, 
      Ministry of Health, Wenzhou, China.
FAU - Wang, Y Q
AU  - Wang YQ
AD  - Division of Ophthalmic Genetics, The Eye Hospital of Wenzhou Medical University, 
      State Key Laboratory Cultivation Base and Key Laboratory of Vision Science, 
      Ministry of Health, Wenzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20160715
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
RN  - 0 (CD59 Antigens)
RN  - 0 (CFH protein, human)
RN  - 101754-01-2 (CD59 protein, human)
RN  - 80295-65-4 (Complement Factor H)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asian People/genetics
MH  - CD59 Antigens/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - China/epidemiology
MH  - Complement Factor H/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Single Nucleotide
MH  - Uveitis, Anterior/*genetics
PMC - PMC5108010
EDAT- 2016/07/16 06:00
MHDA- 2017/07/14 06:00
PMCR- 2017/11/01
CRDT- 2016/07/16 06:00
PHST- 2015/07/24 00:00 [received]
PHST- 2016/06/12 00:00 [accepted]
PHST- 2016/07/16 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
PHST- 2016/07/16 06:00 [entrez]
PHST- 2017/11/01 00:00 [pmc-release]
AID - eye2016146 [pii]
AID - 10.1038/eye.2016.146 [doi]
PST - ppublish
SO  - Eye (Lond). 2016 Nov;30(11):1452-1457. doi: 10.1038/eye.2016.146. Epub 2016 Jul 
      15.