PMID- 27419859
OWN - NLM
STAT- MEDLINE
DCOM- 20171204
LR  - 20180426
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 42
IP  - 3
DP  - 2017 Mar
TI  - Structure-Function Relationship between Flicker-Defined Form Perimetry and 
      Spectral-Domain Optical Coherence Tomography in Glaucoma Suspects.
PG  - 418-423
LID - 10.1080/02713683.2016.1190848 [doi]
AB  - PURPOSE: To evaluate the relationship between functional parameters of repeated 
      flicker-defined form perimetry (FDF) and structural parameters of spectral-domain 
      optical coherence tomography (SD-OCT) in glaucoma suspects with normal findings 
      in achromatic standard automated perimetry (SAP). METHODS: Patients with optic 
      nerve heads (ONH) clinically suspicious for glaucoma and normal SAP findings were 
      enrolled in this prospective study. Each participant underwent visual field (VF) 
      testing with FDF perimetry, using the Heidelberg Edge Perimeter (HEP, Heidelberg 
      Engineering, Heidelberg, Germany) at two consecutive visits. Peripapillary RNFL 
      thickness was obtained by SD-OCT (Spectralis, Heidelberg Engineering, Heidelberg, 
      Germany). Correlations and regression analyses of global and sectoral 
      peripapillary RNFL thickness with corresponding global and regional VF 
      sensitivities were investigated. RESULTS: A consecutive series of 65 study eyes 
      of 36 patients were prospectively included. The second FDF test (HEP II) was used 
      for analysis. Cluster-point based suspicious VF defects were found in 34 eyes 
      (52%). Significant correlations were observed between mean global MD (PSD) of HEP 
      II and SD-OCT-based global peripapillary RNFL thickness (r = 0.380, p = 0.003 for 
      MD and r = -0.516, p < 0.001 for PSD) and RNFL classification scores (R(2) = 
      0.157, p = 0.002 for MD and R(2) = 0.172, p = 0.001 for PSD). Correlations 
      between mean global MD and PSD of HEP II and sectoral peripapillary RNFL 
      thickness and classification scores showed highest correlations between function 
      and structure for the temporal superior and temporal inferior sectors whereas 
      sectoral MD and PSD correlated weaker with sectoral RNFL thickness. Correlations 
      between linear RNFL values and untransformed logarithmic MD values for each 
      segment were less significant than correlations between logarithmic MD values and 
      RNFL thickness. CONCLUSIONS: In glaucoma suspects with normal SAP, global and 
      sectoral peripapillary RNFL thickness is correlated with sensitivity and VF 
      defects in FDF perimetry.
FAU - Reznicek, Lukas
AU  - Reznicek L
AD  - a Department of Ophthalmology , Technical University Munich , Munich , Germany.
FAU - Muth, Daniel
AU  - Muth D
AD  - b Department of Ophthalmology , Ludwig Maximilians University , Munich , Germany.
FAU - Vogel, Michaela
AU  - Vogel M
AD  - b Department of Ophthalmology , Ludwig Maximilians University , Munich , Germany.
FAU - Hirneiss, Christoph
AU  - Hirneiss C
AD  - b Department of Ophthalmology , Ludwig Maximilians University , Munich , Germany.
LA  - eng
PT  - Journal Article
DEP - 20160715
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma/*diagnosis/*physiopathology
MH  - Humans
MH  - *Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Optic Disk/pathology
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Field Tests/*methods
MH  - *Visual Fields
MH  - Young Adult
OTO - NOTNLM
OT  - FDF perimetry
OT  - Glaucoma
OT  - HEP
OT  - OCT
OT  - structure-function
EDAT- 2016/07/16 06:00
MHDA- 2017/12/05 06:00
CRDT- 2016/07/16 06:00
PHST- 2016/07/16 06:00 [pubmed]
PHST- 2017/12/05 06:00 [medline]
PHST- 2016/07/16 06:00 [entrez]
AID - 10.1080/02713683.2016.1190848 [doi]
PST - ppublish
SO  - Curr Eye Res. 2017 Mar;42(3):418-423. doi: 10.1080/02713683.2016.1190848. Epub 
      2016 Jul 15.