PMID- 27420122
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1607-8454 (Electronic)
IS  - 1024-5332 (Linking)
VI  - 6
IP  - 3
DP  - 2001
TI  - Acute Myelogenous Leukaemia in Patients 60 Years and Older: A Retrospective 
      Analysis from St Bartholomew's Hospital 1969-1999.
PG  - 163-75
LID - 10.1080/10245332.2001.11746568 [doi]
AB  - Between 1969 and 1999, 420 patients (age > 60 years) with newly diagnosed AML 
      were managed at St Bartholomew's Hospital (SBH), London, UK. Sixty-nine percent 
      of patients received therapy with curative intent Eighty-eight patients (31%) of 
      the latter achieved complete remission (CR), representing an overall CR rate of 
      21%. Treatment failure due to early death (ED) and resistant disease (RD) 
      occurred in 50 and 19%, respectively. With median follow up of 11 years, 
      actuarial survivals at 1,3 and 5 years were 20, 7 and 4%, respectively, the 
      median survival of the entire cohort was 2 months. For patients who achieved CR, 
      median survival was significantly better than that of patients in whom treatment 
      failed (14 vs. 6 months). Over the 30 years, CR rate and the relative incidence 
      of RD both increased from 13 to 45%, and 3 to 27%, respectively, whilst ED rate 
      reduced from 84 to 27%. Multivariate analysis showed that treatment era, 
      hepatosplenomegaly and increasing age predicted for reduced CR rate and OS. 
      Although elderly patients with AML are characterised by a poor response to 
      intensive chemotherapy, significant improvements in supportive care and the 
      delivery of intensive treatment have led to improved CR rates and OS. New 
      therapeutic strategies and a greater awareness of prognostic factors may further 
      improve clinical outcome in this important group of patients.
FAU - Dalley, C D
AU  - Dalley CD
AD  - a I.C.R.F Medical Oncology Unit , St Bartholomew's Hospital West Smithfield , 
      London , EC1A 7BE , UK.
AD  - b Department of Haematology St Bartholomew's Hospital West Smithfield , London , 
      EC1A 7BE , UK.
FAU - Rohatiner, A Z
AU  - Rohatiner AZ
AD  - a I.C.R.F Medical Oncology Unit , St Bartholomew's Hospital West Smithfield , 
      London , EC1A 7BE , UK.
FAU - Bradburn, M
AU  - Bradburn M
AD  - c I.C.R.F Medical Statistics Group , Institute of Health Sciences , Headington, 
      Oxford , OX3 7LF , UK.
FAU - Lillington, D M
AU  - Lillington DM
AD  - a I.C.R.F Medical Oncology Unit , St Bartholomew's Hospital West Smithfield , 
      London , EC1A 7BE , UK.
FAU - Carter, M
AU  - Carter M
AD  - a I.C.R.F Medical Oncology Unit , St Bartholomew's Hospital West Smithfield , 
      London , EC1A 7BE , UK.
FAU - Slater, S
AU  - Slater S
AD  - a I.C.R.F Medical Oncology Unit , St Bartholomew's Hospital West Smithfield , 
      London , EC1A 7BE , UK.
FAU - MacCallum, P
AU  - MacCallum P
AD  - b Department of Haematology St Bartholomew's Hospital West Smithfield , London , 
      EC1A 7BE , UK.
FAU - Amess, J A
AU  - Amess JA
AD  - b Department of Haematology St Bartholomew's Hospital West Smithfield , London , 
      EC1A 7BE , UK.
FAU - Lister, T A
AU  - Lister TA
AD  - a I.C.R.F Medical Oncology Unit , St Bartholomew's Hospital West Smithfield , 
      London , EC1A 7BE , UK.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hematology
JT  - Hematology (Amsterdam, Netherlands)
JID - 9708388
SB  - IM
OTO - NOTNLM
OT  - Acute myelogenous leukaemia
OT  - Chemotherapy
OT  - Complete remission
OT  - Cytogenetics
OT  - Elderly
EDAT- 2001/01/01 00:00
MHDA- 2001/01/01 00:01
CRDT- 2016/07/16 06:00
PHST- 2016/07/16 06:00 [entrez]
PHST- 2001/01/01 00:00 [pubmed]
PHST- 2001/01/01 00:01 [medline]
AID - 10.1080/10245332.2001.11746568 [doi]
PST - ppublish
SO  - Hematology. 2001;6(3):163-75. doi: 10.1080/10245332.2001.11746568.