PMID- 27420391
OWN - NLM
STAT- MEDLINE
DCOM- 20170614
LR  - 20171217
IS  - 1878-0326 (Electronic)
IS  - 1872-4973 (Linking)
VI  - 24
DP  - 2016 Sep
TI  - Adventitious match probability for autosomal profiles when primer binding site 
      mutation is possible.
PG  - 143-147
LID - S1872-4973(16)30112-0 [pii]
LID - 10.1016/j.fsigen.2016.06.011 [doi]
AB  - This paper considers the situation where two DNA systems with differing primers 
      have been used to produce DNA profiles for loading and searching of a DNA 
      Database. With any profiling system there exists the possibility of a "primer 
      binding site mutation" (PBSM). When such a mutation occurs at one of the loci in 
      a profile, it has the effect that the associated allele is not visible in the 
      profile. In the case where a person has two different alleles at a given locus 
      (heterozygous) the effect of a PBSM would be that the profile would appear to be 
      that of an individual with only one allele at that locus (homozygous). The paper 
      investigates the potential for an adventitious match as a result of a PBSM when, 
      for example, a crime profile and person profile that have originated from two 
      different individuals are found to be the same as a result of a PBSM in one of 
      the profiles. It is demonstrated, both by theory and using simulations, that the 
      effect of PBSMs is to slightly decrease the adventitious match probability from 
      what it would had the same DNA system been used.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Pope, Susan
AU  - Pope S
AD  - Principal Forensic Services, Melbury House, 34 Southborough Road, Bickley, 
      Bromley, Kent BR1 2EB, UK. Electronic address: 
      suepope@principalforensicservices.com.
FAU - Evett, Ian
AU  - Evett I
AD  - Principal Forensic Services, Melbury House, 34 Southborough Road, Bickley, 
      Bromley, Kent BR1 2EB, UK.
FAU - Puch-Solis, Roberto
AU  - Puch-Solis R
AD  - LGC, 3 Drayton Manor Business Park, Tamworth B78 3GL, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160627
PL  - Netherlands
TA  - Forensic Sci Int Genet
JT  - Forensic science international. Genetics
JID - 101317016
RN  - 0 (DNA Primers)
SB  - IM
MH  - *Binding Sites
MH  - *DNA Fingerprinting
MH  - *DNA Primers
MH  - *Databases, Nucleic Acid
MH  - Humans
MH  - *Mutation
MH  - Probability
OTO - NOTNLM
OT  - Adventitious match
OT  - DNA database
OT  - PCR chemistry
OT  - Primer binding site mutation
EDAT- 2016/07/16 06:00
MHDA- 2017/06/15 06:00
CRDT- 2016/07/16 06:00
PHST- 2015/12/16 00:00 [received]
PHST- 2016/05/18 00:00 [revised]
PHST- 2016/06/17 00:00 [accepted]
PHST- 2016/07/16 06:00 [entrez]
PHST- 2016/07/16 06:00 [pubmed]
PHST- 2017/06/15 06:00 [medline]
AID - S1872-4973(16)30112-0 [pii]
AID - 10.1016/j.fsigen.2016.06.011 [doi]
PST - ppublish
SO  - Forensic Sci Int Genet. 2016 Sep;24:143-147. doi: 10.1016/j.fsigen.2016.06.011. 
      Epub 2016 Jun 27.