PMID- 27421479
OWN - NLM
STAT- MEDLINE
DCOM- 20170802
LR  - 20191210
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Linking)
VI  - 197
IP  - 4
DP  - 2016 Aug 15
TI  - Cutting Edge: ACVRL1 Signaling Augments CD8alpha+ Dendritic Cell Development.
PG  - 1029-34
LID - 10.4049/jimmunol.1501849 [doi]
AB  - Dendritic cells (DCs) are a collection of different subtypes, each of which is 
      characterized by specific surface markers, gene-expression patterns, and distinct 
      functions. Members of the IFN regulatory factor family play critical roles in DC 
      development and functions. Recently, Irf8 was shown to activate TGF-beta signaling, 
      which led to exacerbated neuroinflammation in the experimental autoimmune 
      encephalomyelitis mouse model. We analyzed the effect of Irf8 on TGF-beta/bone 
      morphogenetic protein pathway-specific genes in DCs and identified Acvrl1, a type 
      I TGF-beta superfamily receptor, as a gene strongly induced by Irf8 expression. 
      Among various DC subtypes, Acvrl1 is differentially expressed in CD8alpha(+) DCs. 
      ACVRL1 signaling augmented Irf8-directed classical CD8alpha(+) DC development. Irf8 
      expression is essential for plasmacytoid DC and CD8alpha(+) DC development, and this 
      study demonstrates that ACVRL1 signaling plays a pivotal role whereby it 
      suppresses plasmacytoid DC development while enhancing that of CD8alpha(+) DCs, thus 
      contributing to DC diversity development.
CI  - Copyright (c) 2016 by The American Association of Immunologists, Inc.
FAU - Verma, Rohit
AU  - Verma R
AD  - Laboratory of Innate Immunity, National Institute of Immunology, New Delhi, Delhi 
      110067, India.
FAU - Jaiswal, Hemant
AU  - Jaiswal H
AD  - Laboratory of Innate Immunity, National Institute of Immunology, New Delhi, Delhi 
      110067, India.
FAU - Chauhan, Kuldeep Singh
AU  - Chauhan KS
AD  - Laboratory of Innate Immunity, National Institute of Immunology, New Delhi, Delhi 
      110067, India.
FAU - Kaushik, Monika
AU  - Kaushik M
AD  - Laboratory of Innate Immunity, National Institute of Immunology, New Delhi, Delhi 
      110067, India.
FAU - Tailor, Prafullakumar
AU  - Tailor P
AD  - Laboratory of Innate Immunity, National Institute of Immunology, New Delhi, Delhi 
      110067, India tailorp@nii.ac.in.
LA  - eng
PT  - Journal Article
DEP - 20160715
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (CD8 Antigens)
RN  - 0 (CD8 antigen, alpha chain)
RN  - 0 (Interferon Regulatory Factors)
RN  - 0 (interferon regulatory factor-8)
RN  - EC 2.7.11.30 (Activin Receptors, Type I)
RN  - EC 2.7.11.30 (Activin Receptors, Type II)
RN  - EC 2.7.11.30 (Acvrl1 protein, mouse)
SB  - IM
MH  - Activin Receptors, Type I/immunology/*metabolism
MH  - Activin Receptors, Type II
MH  - Animals
MH  - CD8 Antigens/immunology
MH  - Cell Differentiation/*immunology
MH  - Dendritic Cells/*cytology/*immunology/metabolism
MH  - Interferon Regulatory Factors/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Signal Transduction/*immunology
EDAT- 2016/07/17 06:00
MHDA- 2017/08/03 06:00
CRDT- 2016/07/17 06:00
PHST- 2015/08/19 00:00 [received]
PHST- 2016/06/16 00:00 [accepted]
PHST- 2016/07/17 06:00 [entrez]
PHST- 2016/07/17 06:00 [pubmed]
PHST- 2017/08/03 06:00 [medline]
AID - jimmunol.1501849 [pii]
AID - 10.4049/jimmunol.1501849 [doi]
PST - ppublish
SO  - J Immunol. 2016 Aug 15;197(4):1029-34. doi: 10.4049/jimmunol.1501849. Epub 2016 
      Jul 15.