PMID- 27422240
OWN - NLM
STAT- MEDLINE
DCOM- 20170703
LR  - 20180307
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 55
IP  - 3
DP  - 2017 Mar
TI  - Muscle action potential scans and ultrasound imaging in neurofibromatosis type 2.
PG  - 350-358
LID - 10.1002/mus.25256 [doi]
AB  - INTRODUCTION: The neuropathy in patients with neurofibromatosis type 2 (NF2) is 
      difficult to quantify and follow up. In this study we compared 3 methods that may 
      help assess motor axon pathology in NF2 patients. METHODS: Nerve conduction 
      studies in median nerves were supplemented by deriving motor unit number 
      estimates (MUNEs) from compound muscle action potential (CMAP) scans and by 
      high-resolution ultrasound (US) peripheral nerve imaging. RESULTS: CMAP 
      amplitudes and nerve conduction velocity were normal in the vast majority of 
      affected individuals, but CMAP scan MUNE revealed denervation and reinnervation 
      in many peripheral nerves. In addition, nerve US imaging enabled monitoring of 
      the size and number of schwannoma-like fascicular enlargements in median nerve 
      trunks. CONCLUSION: In contrast to conventional nerve conduction studies, CMAP 
      scan MUNE in combination with US nerve imaging can quantify the NF2-associated 
      neuropathy and may help to monitor disease progression and drug treatments. 
      Muscle Nerve 55: 350-358, 2017.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Farschtschi, Said
AU  - Farschtschi S
AD  - Department of Neurology, University Medical Centre Hamburg-Eppendorf Hospital, 
      Hamburg, Germany.
FAU - Gelderblom, Mathias
AU  - Gelderblom M
AD  - Department of Neurology, University Medical Centre Hamburg-Eppendorf Hospital, 
      Hamburg, Germany.
FAU - Buschbaum, Sabriena
AU  - Buschbaum S
AD  - Department of Neurology, University Medical Centre Hamburg-Eppendorf Hospital, 
      Hamburg, Germany.
FAU - Bostock, Hugh
AU  - Bostock H
AD  - Sobell Department of Motor Neuroscience and Movement Disorders, Institute of 
      Neurology, University College London, London, UK.
FAU - Grafe, Peter
AU  - Grafe P
AD  - Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University 
      Munich, Pettenkoferstrasse 12, 80336, Munich, Germany.
FAU - Mautner, Victor F
AU  - Mautner VF
AD  - Department of Neurology, University Medical Centre Hamburg-Eppendorf Hospital, 
      Hamburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161216
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Action Potentials/*physiology
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Electrophysiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Neurons/physiology
MH  - Muscle, Skeletal/*diagnostic imaging/*physiopathology
MH  - Neural Conduction/physiology
MH  - Neurofibromatosis 2/complications/*diagnostic imaging/*pathology
MH  - Peripheral Nerves/diagnostic imaging
MH  - *Ultrasonography
MH  - Young Adult
OTO - NOTNLM
OT  - MUNE
OT  - denervation
OT  - neurofibromatosis type 2
OT  - neuropathy
OT  - reinnervation
OT  - ultrasound nerve imaging
EDAT- 2016/07/17 06:00
MHDA- 2017/07/04 06:00
CRDT- 2016/07/17 06:00
PHST- 2016/07/12 00:00 [accepted]
PHST- 2016/07/17 06:00 [pubmed]
PHST- 2017/07/04 06:00 [medline]
PHST- 2016/07/17 06:00 [entrez]
AID - 10.1002/mus.25256 [doi]
PST - ppublish
SO  - Muscle Nerve. 2017 Mar;55(3):350-358. doi: 10.1002/mus.25256. Epub 2016 Dec 16.