PMID- 27422865
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1477-111X (Electronic)
IS  - 0267-6591 (Linking)
VI  - 31
IP  - 8
DP  - 2016 Nov
TI  - Early improvement of symptoms using LCZ696 in a patient with systolic heart 
      failure and a reduced ejection fraction: a case report.
PG  - 699-702
LID - 10.1177/0267659116660608 [doi]
AB  - INTRODUCTION: Heart failure is a progressive disease with high mortality and 
      morbidity. LCZ696 is a drug that has recently shown its improved efficacy and 
      safety in patients with systolic heart failure and a reduced ejection fraction. 
      Reports on its impact on the improvement of clinical symptoms are, however, 
      scarce. These are important because they improve a patient's compliance with 
      treatment and their quality of life. CASE PRESENTATION: We report on the case of 
      a 71-year-old patient who had deteriorating symptoms and signs of heart failure 
      (ejection fraction [EF] 34%) in whom we initiated LCZ696 treatment. After two 
      months of LCZ696 treatment (including titration), the New York Heart Association 
      (NYHA) classification had improved (III-->II/I) with no residual signs of 
      acrocyanosis and orthopnea. While creatinine values remained stable, potassium 
      increased to 5.0 mmol/l and brain natriuretic peptide (BNP) dropped from 1260 
      ng/l to 680 ng/ml. The final EF was 47%. The patient reported substantial 
      improvement of his quality of life. CONCLUSION: We show, based on a case report, 
      that symptoms associated with heart failure deterioration are improved early 
      after the initiation of LCZ696. This should foster specific research into 
      symptoms and quality of life improvements with LCZ696.
FAU - Kohlmeier, Johannes
AU  - Kohlmeier J
AD  - 1 Privatpraxis Dr. Kohlmeier, Burgermeister-Aurnhammer-Str. 13, 86199 Augsburg, 
      Germany.
FAU - Bramlage, Peter
AU  - Bramlage P
AD  - 2 Institut fur Pharmakologie und Praventive Medizin, Menzelstrasse 21, 15831 
      Mahlow, Germany.
LA  - eng
PT  - Journal Article
DEP - 20160718
PL  - England
TA  - Perfusion
JT  - Perfusion
JID - 8700166
OTO - NOTNLM
OT  - LCZ696
OT  - heart failure
OT  - neprilysin
OT  - quality of life
OT  - symptoms
EDAT- 2016/07/17 06:00
MHDA- 2016/07/17 06:01
CRDT- 2016/07/17 06:00
PHST- 2016/07/17 06:00 [pubmed]
PHST- 2016/07/17 06:01 [medline]
PHST- 2016/07/17 06:00 [entrez]
AID - 0267659116660608 [pii]
AID - 10.1177/0267659116660608 [doi]
PST - ppublish
SO  - Perfusion. 2016 Nov;31(8):699-702. doi: 10.1177/0267659116660608. Epub 2016 Jul 
      18.