PMID- 27424000
OWN - NLM
STAT- MEDLINE
DCOM- 20170309
LR  - 20170309
IS  - 1096-0295 (Electronic)
IS  - 0273-2300 (Linking)
VI  - 80
DP  - 2016 Oct
TI  - Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin 
      sensitization potency. Part 1. Underlying physical organic chemistry principles 
      and the extent to which they are represented in the LLNA validation dataset.
PG  - 247-54
LID - S0273-2300(16)30190-8 [pii]
LID - 10.1016/j.yrtph.2016.07.007 [doi]
FAU - Roberts, D W
AU  - Roberts DW
AD  - School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, 
      Liverpool L3 3AF, United Kingdom. Electronic address: D.W.Roberts@ljmu.ac.uk.
FAU - Api, A M
AU  - Api AM
AD  - Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff 
      Lake, NJ 07677, USA.
FAU - Patlewicz, G
AU  - Patlewicz G
AD  - DuPont Haskell Global Centers, 1090 Elkton Road, Newark, DE 19711, USA.
FAU - Schultz, T W
AU  - Schultz TW
AD  - The University of Tennessee, College of Veterinary, 2407 River Drive, Knoxville, 
      TN 37996, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160714
PL  - Netherlands
TA  - Regul Toxicol Pharmacol
JT  - Regulatory toxicology and pharmacology : RTP
JID - 8214983
RN  - 0 (Irritants)
SB  - IM
MH  - Administration, Cutaneous
MH  - Animals
MH  - Data Mining
MH  - Databases, Factual
MH  - Dermatitis, Allergic Contact/*etiology/immunology
MH  - Dose-Response Relationship, Drug
MH  - Guinea Pigs
MH  - Humans
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Irritants/chemistry/metabolism/*toxicity
MH  - *Local Lymph Node Assay
MH  - Lymph Nodes/*drug effects/pathology
MH  - *Models, Molecular
MH  - Molecular Structure
MH  - Skin/*drug effects/immunology/metabolism
MH  - Skin Absorption
MH  - Species Specificity
MH  - Structure-Activity Relationship
OTO - NOTNLM
OT  - Electrophilicity
OT  - Hydrophobicity
OT  - Reactivity
OT  - Relative Alkylation Index (RAI)
OT  - Skin penetration
OT  - Skin sensitization
EDAT- 2016/07/18 06:00
MHDA- 2017/03/10 06:00
CRDT- 2016/07/18 06:00
PHST- 2016/04/24 00:00 [received]
PHST- 2016/07/06 00:00 [revised]
PHST- 2016/07/11 00:00 [accepted]
PHST- 2016/07/18 06:00 [entrez]
PHST- 2016/07/18 06:00 [pubmed]
PHST- 2017/03/10 06:00 [medline]
AID - S0273-2300(16)30190-8 [pii]
AID - 10.1016/j.yrtph.2016.07.007 [doi]
PST - ppublish
SO  - Regul Toxicol Pharmacol. 2016 Oct;80:247-54. doi: 10.1016/j.yrtph.2016.07.007. 
      Epub 2016 Jul 14.