PMID- 27424266 OWN - NLM STAT- MEDLINE DCOM- 20171221 LR - 20180111 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 176 IP - 2-3 DP - 2016 Oct TI - Peripheral immuno-inflammatory abnormalities in ultra-high risk of developing psychosis. PG - 191-195 LID - S0920-9964(16)30313-9 [pii] LID - 10.1016/j.schres.2016.06.031 [doi] AB - BACKGROUND: Immuno-inflammatory imbalances have been documented in schizophrenia, but very little is known about the immunological changes prior to the onset of disease. OBJECTIVE: This work aimed to compare serum levels of pro- and anti-inflammatory cytokines in young subjects at ultra-high risk (UHR) of developing psychosis with age- and sex-matched healthy controls. METHODS: A total of 12 UHR and 16 age- and sex-matched healthy controls (HC) subjects were enrolled in this study. Clinical profile was assessed using the Comprehensive Assessment of At-Risk Mental States (CAARMS), Semi-Structured Clinical Interview for DSM-IV Axis-I (SCID-I) or Kiddie-SADS-Present and Lifetime Version (K-SADS-PL), and Global Assessment of Functioning (GAF) scale. Serum interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-alpha, IFN-gamma, and IL-17 were measured by flow cytometry using the Th1/Th2/Th17 cytometric bead array. RESULTS: Compared with the healthy control group, patients in UHR showed increased IL-6 levels (Z=-2.370, p=0.018) and decreased IL-17 levels in serum (Z=-1.959, p=0.050). Levels of IL-17 positively correlated to the values in GAF symptoms (rho=0.632, p=0.028). CONCLUSION: Our results suggest that immunological imbalances could be present in the early stages of psychosis, including in at-risk stages. Future studies should replicate and expand these results. CI - Copyright (c) 2016 Elsevier B.V. All rights reserved. FAU - Zeni-Graiff, Maiara AU - Zeni-Graiff M AD - Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), Sao Paulo, Brazil; Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil; Research Group on Behavioral and Molecular Neuroscience of Bipolar Disorder, Sao Paulo, Brazil. FAU - Rizzo, Lucas B AU - Rizzo LB AD - Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil; Research Group on Behavioral and Molecular Neuroscience of Bipolar Disorder, Sao Paulo, Brazil; Department of Psychiatry, University of Tubingen, Tubingen, Germany. FAU - Mansur, Rodrigo B AU - Mansur RB AD - Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), Sao Paulo, Brazil; Mood Disorders Psychopharmacology Unit (MDPU), University Health Network (UHN), University of Toronto, Toronto, Canada. FAU - Maurya, Pawan K AU - Maurya PK AD - Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil; Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, India. FAU - Sethi, Sumit AU - Sethi S AD - Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil. FAU - Cunha, Graccielle R AU - Cunha GR AD - Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), Sao Paulo, Brazil; Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil; Research Group on Behavioral and Molecular Neuroscience of Bipolar Disorder, Sao Paulo, Brazil. FAU - Asevedo, Elson AU - Asevedo E AD - Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), Sao Paulo, Brazil; Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil; Research Group on Behavioral and Molecular Neuroscience of Bipolar Disorder, Sao Paulo, Brazil. FAU - Pan, Pedro AU - Pan P AD - Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), Sao Paulo, Brazil; Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil; Research Group on Behavioral and Molecular Neuroscience of Bipolar Disorder, Sao Paulo, Brazil. FAU - Zugman, Andre AU - Zugman A AD - Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), Sao Paulo, Brazil; Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil; Research Group on Behavioral and Molecular Neuroscience of Bipolar Disorder, Sao Paulo, Brazil. FAU - Yamagata, Ana S AU - Yamagata AS AD - Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), Sao Paulo, Brazil; Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil; Research Group on Behavioral and Molecular Neuroscience of Bipolar Disorder, Sao Paulo, Brazil. FAU - Higuchi, Cinthia AU - Higuchi C AD - Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), Sao Paulo, Brazil; Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil. FAU - Bressan, Rodrigo A AU - Bressan RA AD - Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), Sao Paulo, Brazil; Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil. FAU - Gadelha, Ary AU - Gadelha A AD - Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), Sao Paulo, Brazil; Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil; Research Group on Behavioral and Molecular Neuroscience of Bipolar Disorder, Sao Paulo, Brazil. FAU - Brietzke, Elisa AU - Brietzke E AD - Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), Sao Paulo, Brazil; Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil; Research Group on Behavioral and Molecular Neuroscience of Bipolar Disorder, Sao Paulo, Brazil. Electronic address: elisabrietzke@hotmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160808 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 RN - 0 (Antipsychotic Agents) RN - 0 (Biomarkers) RN - 0 (Cytokines) SB - IM MH - Adolescent MH - Antipsychotic Agents/therapeutic use MH - Biomarkers/blood MH - Cross-Sectional Studies MH - Cytokines/*blood MH - Female MH - Humans MH - Interview, Psychological MH - Male MH - Psychiatric Status Rating Scales MH - Psychotic Disorders/*blood/drug therapy/*immunology MH - Risk MH - Young Adult OTO - NOTNLM OT - Cytokines OT - Inflammation OT - Prodromal OT - Psychosis OT - Schizophrenia OT - Ultra-high risk EDAT- 2016/07/18 06:00 MHDA- 2017/12/22 06:00 CRDT- 2016/07/18 06:00 PHST- 2016/04/04 00:00 [received] PHST- 2016/06/21 00:00 [revised] PHST- 2016/06/25 00:00 [accepted] PHST- 2016/07/18 06:00 [entrez] PHST- 2016/07/18 06:00 [pubmed] PHST- 2017/12/22 06:00 [medline] AID - S0920-9964(16)30313-9 [pii] AID - 10.1016/j.schres.2016.06.031 [doi] PST - ppublish SO - Schizophr Res. 2016 Oct;176(2-3):191-195. doi: 10.1016/j.schres.2016.06.031. Epub 2016 Aug 8.