PMID- 27424992
OWN - NLM
STAT- MEDLINE
DCOM- 20170821
LR  - 20181202
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 20
IP  - 13
DP  - 2016 Jul
TI  - Bone marrow cells differentiation into organ cells using stem cell therapy.
PG  - 2899-907
LID - 11118 [pii]
AB  - Bone marrow cells (BMC) are progenitors of bone, cartilage, skeletal tissue, the 
      hematopoiesis-supporting stroma and adipocyte cells. BMCs have the potential to 
      differentiate into neural cells, cardiac myocytes, liver hepatocytes, 
      chondrocytes, renal, corneal, blood, and myogenic cells. The bone marrow cell 
      cultures from stromal and mesenchymal cells are called multipotent adult 
      progenitor cells (MAPCs). MAPCs can differentiate into mesenchymal cells, 
      visceral mesoderm, neuroectoderm and endoderm in vitro. It has been shown that 
      the stem cells derived from bone marrow cells (BMCs) can regenerate cardiac 
      myocytes after myocardial infarction (MI). Adult bone marrow mesenchymal stem 
      cells have the ability to regenerate neural cells. Neural stem/progenitor cells 
      (NS/PC) are ideal for treating central nervous system (CNS) diseases, such as 
      Alzheimer's, Parkinson's and Huntington disease. However, there are important 
      ethical issues about the therapeutic use of stem cells. Neurons, cardiac 
      myocytes, hepatocytes, renal cells, blood cells, chondrocytes and adipocytes 
      regeneration from BMCs are very important in disease control. It is known that 
      limbal epithelial stem cells in the cornea can repair the eye sight and remove 
      symptoms of blindness. Stem cell therapy (SCT) is progressing well in animal 
      models, but the use of SCT in human remains to be explored further.
FAU - Yang, Y-J
AU  - Yang YJ
AD  - Department of Hematology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China. 
      xzyyj2013@126.com.
FAU - Li, X-L
AU  - Li XL
FAU - Xue, Y
AU  - Xue Y
FAU - Zhang, C-X
AU  - Zhang CX
FAU - Wang, Y
AU  - Wang Y
FAU - Hu, X
AU  - Hu X
FAU - Dai, Q
AU  - Dai Q
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/*cytology
MH  - *Cell Differentiation
MH  - *Cell- and Tissue-Based Therapy
MH  - Humans
MH  - Mesenchymal Stem Cells/*cytology
MH  - *Stem Cell Transplantation
EDAT- 2016/07/19 06:00
MHDA- 2017/08/22 06:00
CRDT- 2016/07/19 06:00
PHST- 2016/07/19 06:00 [entrez]
PHST- 2016/07/19 06:00 [pubmed]
PHST- 2017/08/22 06:00 [medline]
AID - 11118 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2016 Jul;20(13):2899-907.