PMID- 27427341
OWN - NLM
STAT- MEDLINE
DCOM- 20170317
LR  - 20170317
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 66
IP  - 8
DP  - 2016 Aug
TI  - Presence of Citrullinated Histone H3-Positive Neutrophils in Microscopic 
      Polyangiitis from the Early Phase: An Autopsy Proven Case.
PG  - 466-71
LID - 10.1111/pin.12434 [doi]
AB  - A 76-year-old man was admitted with general fatigue, weight loss, fever, 
      headache, renal failure, and a high serum level of myeloperoxidase-antineutrophil 
      cytoplasmic antibody. Biopsy revealed citrullinated histone H3 (citH3)-positive 
      neutrophils adherent to the temporal artery endothelium. Three days after 
      completing pulse steroid therapy, he suffered from a sudden disturbance of 
      consciousness and died. On autopsy, the kidneys showed the most severe vasculitis 
      with dense infiltration of citH3-positive neutrophils. The lungs showed 
      intra-alveolar hemorrhage due to capillaritis. Severe brain hemorrhage was found 
      in the left frontal lobe and putamen with uncal herniation. No vasculitis or 
      thrombi was observed in the brain. The right dura mater was thickened due to 
      fibrosis and inflammation. In conclusion, autopsy revealed systemic vasculitis 
      with infiltration of abundant citH3-positive neutrophils, suggesting that the 
      neutrophil extracellular trap formation and citH3 might play important roles in 
      the early phases and development of microscopic polyangiitis.
CI  - (c) 2016 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.
FAU - Matsuda, Yoko
AU  - Matsuda Y
AD  - Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
FAU - Hamayasu, Hideki
AU  - Hamayasu H
AD  - Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
FAU - Seki, Atsuko
AU  - Seki A
AD  - Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
FAU - Nonaka, Keisuke
AU  - Nonaka K
AD  - Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
FAU - Wang, Tan
AU  - Wang T
AD  - Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
AD  - Department of Pathology, Henan University of Traditional Chinese Medicine, 
      ZhengZhou, China.
FAU - Matsumoto, Takumi
AU  - Matsumoto T
AD  - Department of Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
FAU - Hamano, Yoshitomo
AU  - Hamano Y
AD  - Department of Nephrology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
FAU - Sumikura, Hiroyuki
AU  - Sumikura H
AD  - Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan 
      Institute of Gerontology, Tokyo, Japan.
FAU - Kumasaka, Toshio
AU  - Kumasaka T
AD  - Department of Pathology, Japanese Red Cross Medical Center, Tokyo, Japan.
FAU - Murayama, Shigeo
AU  - Murayama S
AD  - Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan 
      Institute of Gerontology, Tokyo, Japan.
FAU - Ishizu, Akihiko
AU  - Ishizu A
AD  - Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
FAU - Shimizu, Akira
AU  - Shimizu A
AD  - Department of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan.
FAU - Sugihara, Takahiko
AU  - Sugihara T
AD  - Department of Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
FAU - Arai, Tomio
AU  - Arai T
AD  - Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
AD  - Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of 
      Gerontology, Tokyo, Japan.
LA  - eng
PT  - Case Reports
DEP - 20160718
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Histones)
RN  - 29VT07BGDA (Citrulline)
SB  - IM
MH  - Aged
MH  - Autopsy
MH  - Citrulline
MH  - *Extracellular Traps
MH  - Histones/*metabolism
MH  - Humans
MH  - Male
MH  - Microscopic Polyangiitis/*pathology
MH  - Neutrophils/*pathology
OTO - NOTNLM
OT  - citrullinated histone H3
OT  - elderly
OT  - microscopic polyangiitis
OT  - myeloperoxidase-antineutrophil cytoplasmic antibody
OT  - neutrophil extracellular trap
EDAT- 2016/07/19 06:00
MHDA- 2017/03/18 06:00
CRDT- 2016/07/19 06:00
PHST- 2015/12/30 00:00 [received]
PHST- 2016/04/26 00:00 [revised]
PHST- 2016/05/28 00:00 [accepted]
PHST- 2016/07/19 06:00 [entrez]
PHST- 2016/07/19 06:00 [pubmed]
PHST- 2017/03/18 06:00 [medline]
AID - 10.1111/pin.12434 [doi]
PST - ppublish
SO  - Pathol Int. 2016 Aug;66(8):466-71. doi: 10.1111/pin.12434. Epub 2016 Jul 18.