PMID- 2742782
OWN - NLM
STAT- MEDLINE
DCOM- 19890818
LR  - 20090512
IS  - 0284-186X (Print)
IS  - 0284-186X (Linking)
VI  - 28
IP  - 3
DP  - 1989
TI  - Interferon treatment in patients with malignant carcinoids.
PG  - 445-9
AB  - Thirteen patients with ileal carcinoids complicated by liver metastases were 
      treated with human leukocyte interferon (IFN) subcutaneously (s.c.) at doses of 
      3-6 x 10(6) IU/day 5 days weekly during 12 months. Objective tumour response was 
      obtained in 2 patients, based on reduction in tumour size in one patient and on 
      reduction in tumour markers in the other. Stable disease was noted during the 
      12-month treatment period in 10 patients. Progressive disease was seen in one 
      patient. This patient exhibited tumour growth, new metastases and increases in 
      tumour markers. Among patients with daily flushing prior to treatment, 50% were 
      free of flush after 12 months of IFN. Adverse effects, including a mild 
      influenza-like syndrome, joint and muscle pains, tiredness and reduction of blood 
      cells were observed but did not necessitate long-term dose reductions. Thus, IFN 
      therapy to midgut carcinoid patients resulted in tumour response or stable 
      disease in 12 out of 13 patients without causing severe side effects.
FAU - Nobin, A
AU  - Nobin A
AD  - Department of Surgery, University of Lund, Sweden.
FAU - Lindblom, A
AU  - Lindblom A
FAU - Mansson, B
AU  - Mansson B
FAU - Sundberg, M
AU  - Sundberg M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Acta Oncol
JT  - Acta oncologica (Stockholm, Sweden)
JID - 8709065
RN  - 0 (Interferon Type I)
SB  - IM
MH  - Aged
MH  - Bone Neoplasms/secondary
MH  - Carcinoid Tumor/secondary/*therapy
MH  - Female
MH  - Humans
MH  - Ileal Neoplasms/therapy
MH  - Interferon Type I/adverse effects/*therapeutic use
MH  - Liver Neoplasms/secondary/therapy
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Remission Induction
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.3109/02841868909111220 [doi]
PST - ppublish
SO  - Acta Oncol. 1989;28(3):445-9. doi: 10.3109/02841868909111220.