PMID- 27428175
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20221207
IS  - 1744-5078 (Electronic)
IS  - 0927-3948 (Linking)
VI  - 26
IP  - 1
DP  - 2018
TI  - Ankylosing Spondylitis Patients with HLA-B*2704 have More Uveitis than Patients 
      with HLA-B*2705 in a North Chinese Population.
PG  - 65-69
LID - 10.1080/09273948.2016.1188967 [doi]
AB  - PURPOSE: To investigate the correlation between clinical features of ankylosing 
      spondylitis (AS) and different human leukocyte antigen (HLA)-B27 subtypes. 
      METHODS: We conducted a cross-sectional study of 216 patients with AS. HLA-B27 
      and its subtypes were detected by polymerase chain reaction with sequence 
      specific primer (PCR-SSP). Clinical features were compared between the different 
      HLA-B27 subtypes. A meta-analysis on uveitis frequencies in AS patients with 
      HLA-B*2705 vs 2704 was performed. RESULTS: The most prevalent subtypes of HLA-B27 
      were HLA-B*2704 (66.1%) and HLA-B*2705 (32.2%). There were 57 HLA-B27-positive AS 
      patients with the history of uveitis; 45 were B*2704 and 12 were B*2705. Patients 
      with B*2704 had more uveitis than B*2705 (p = 0.021). After meta-analysis, there 
      was no significant difference in the presence of uveitis between HLA-B*2704 and 
      HLA-B*2705. CONCLUSIONS: AS patients with B*2704 have a higher risk of uveitis 
      than AS with B*2705 in a north Chinese people.
FAU - Li, Haibo
AU  - Li H
AD  - a Third Affiliated Hospital of Sun Yat-sen University, General Hospital of 
      Ningxia Medical University , Department of Rheumatology , Yinchuan , China.
FAU - Li, Qiuxia
AU  - Li Q
AD  - b Third Affiliated Hospital of Sun Yat-sen University , Department of 
      Rheumatology , Guangzhou , China.
FAU - Ji, Chen
AU  - Ji C
AD  - c General Hospital of Ningxia Medical University , Department of Rheumatology , 
      Yinchuan , China.
FAU - Gu, Jieruo
AU  - Gu J
AD  - b Third Affiliated Hospital of Sun Yat-sen University , Department of 
      Rheumatology , Guangzhou , China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160718
PL  - England
TA  - Ocul Immunol Inflamm
JT  - Ocular immunology and inflammation
JID - 9312169
RN  - 0 (DNA Primers)
RN  - 0 (HLA-B*27:04 antigen)
RN  - 0 (HLA-B*27:05 antigen)
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adult
MH  - Asian People/*genetics
MH  - China
MH  - Cross-Sectional Studies
MH  - DNA Primers/chemistry
MH  - Female
MH  - HLA-B27 Antigen/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Spondylitis, Ankylosing/diagnosis/*genetics
MH  - Uveitis/diagnosis/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Ankylosing spondylitis
OT  - Chinese
OT  - HLA-B*2704
OT  - HLA-B*2705
OT  - uveitis
EDAT- 2016/07/19 06:00
MHDA- 2018/08/28 06:00
CRDT- 2016/07/19 06:00
PHST- 2016/07/19 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2016/07/19 06:00 [entrez]
AID - 10.1080/09273948.2016.1188967 [doi]
PST - ppublish
SO  - Ocul Immunol Inflamm. 2018;26(1):65-69. doi: 10.1080/09273948.2016.1188967. Epub 
      2016 Jul 18.