PMID- 27428361
OWN - NLM
STAT- MEDLINE
DCOM- 20180427
LR  - 20180427
IS  - 1744-5078 (Electronic)
IS  - 0927-3948 (Linking)
VI  - 25
IP  - 4
DP  - 2017 Aug
TI  - Clinical Spectrum of HLA-B27-associated Ocular Inflammation.
PG  - 569-576
LID - 10.1080/09273948.2016.1185527 [doi]
AB  - Human leukocyte antigen (HLA)-B27-associated anterior uveitis (AU) is the most 
      commonly diagnosed form of AU and represents the largest entity of non-infectious 
      uveitis around the world. The most typical ocular manifestation associated with 
      HLA-B27 consists of unilateral AU of acute onset. The HLA-B27-associated acute AU 
      represents a distinct clinical entity occurring typically in young adults between 
      the ages of 20 and 40 years. HLA-B27-associated acute AU is typically unilateral 
      and lasts usually several weeks and diminishes within 3 months in the majority of 
      patients. The anterior chamber shows typically severe cellular reaction and 
      flare, as well as a fibrinous exudate. Frequently, posterior synechiae are formed 
      and occasionally hypopyon is present. The pattern of the disease is recurrent 
      with a full remission between the attacks. Intraocular pressure during active 
      periods is typically low due to inflammation of ciliary body and decreased 
      aqueous production. Less typical presentations are also recognized and include 
      the development of chronic inflammation, posterior segment involvement, 
      episcleritis, and scleritis. An isolated retinal vasculitis in HLA-B27-positive 
      patients may develop, mostly in those with inflammatory bowel disease. Chronic 
      AU, which may be either unilateral or bilateral affects up to 20% of patients. 
      Ocular complications of HLA-B27-associated AU are diverse and include commonly 
      posterior synechiae, cataract, glaucoma and/or hypotony. The visual outcome and 
      complications of HLA-B27-associated AAU are frequently being compared with HLA 
      B27-negative patients with AU and show that the prognosis of HLA-B27-associated 
      uveitis is rather favorable, as <2% developed legal blindness and <5% visual 
      impairment. A novel algorithm called the "Dublin Uveitis Evaluation Tool (DUET)" 
      has been proposed to guide ophthalmologists to refer appropriate HLA-B27-positive 
      patients with uveitis to rheumatologists.
FAU - Pathanapitoon, Kessara
AU  - Pathanapitoon K
AD  - a Department of Ophthalmology, Faculty of Medicine , Chiang Mai University , 
      Thailand.
FAU - Dodds, Emilio M
AU  - Dodds EM
AD  - b Consultores Oftalmologicos, Hospital Juan A. Fernandez , Buenos Aires , 
      Argentina.
FAU - Cunningham, Emmett T Jr
AU  - Cunningham ET Jr
AD  - c The Department of Ophthalmology , California Pacific Medical Center , San 
      Francisco , California , USA.
AD  - d Department of Ophthalmology , Stanford University School of Medicine , Stanford 
      , California , USA.
AD  - e The Francis I. Proctor Foundation , UCSF School of Medicine , San Francisco , 
      California , USA.
AD  - f West Coast Retina Medical Group , San Francisco , California , USA.
FAU - Rothova, Aniki
AU  - Rothova A
AD  - g Department of Ophthalmology , Erasmus Medical Center , Rotterdam , The 
      Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160718
PL  - England
TA  - Ocul Immunol Inflamm
JT  - Ocular immunology and inflammation
JID - 9312169
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - HLA-B27 Antigen/*immunology
MH  - Humans
MH  - Inflammation/diagnosis/immunology
MH  - Uveitis, Anterior/*diagnosis/epidemiology/*immunology
OTO - NOTNLM
OT  - HLA B27-associated uveitis
OT  - acute anterior uveitis
OT  - anterior uveitis
OT  - clinical manifestations
EDAT- 2016/07/19 06:00
MHDA- 2018/04/28 06:00
CRDT- 2016/07/19 06:00
PHST- 2016/07/19 06:00 [pubmed]
PHST- 2018/04/28 06:00 [medline]
PHST- 2016/07/19 06:00 [entrez]
AID - 10.1080/09273948.2016.1185527 [doi]
PST - ppublish
SO  - Ocul Immunol Inflamm. 2017 Aug;25(4):569-576. doi: 10.1080/09273948.2016.1185527. 
      Epub 2016 Jul 18.