PMID- 27429111
OWN - NLM
STAT- MEDLINE
DCOM- 20170403
LR  - 20200228
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Linking)
VI  - 65
IP  - 5
DP  - 2016 Nov 23
TI  - Depletion of alveolar macrophages attenuates hypoxic pulmonary hypertension but 
      not hypoxia-induced increase in serum concentration of MCP-1.
PG  - 763-768
AB  - Exposure to hypoxia, leading to hypoxic pulmonary hypertension (HPH), is 
      associated with activation of alveolar macrophages (AM). However, it remains 
      unclear how AM participate in this process. There are studies which imply that 
      the AM product monocyte chemoattractant protein-1 (MCP-1) plays an important 
      role. Thus we tested: 1. if the selective elimination of AM attenuates HPH in 
      rats, 2. the correlation of MCP-1 plasmatic concentrations with the presence and 
      absence of AM during exposure to hypoxia, 3. the direct influence of hypoxia on 
      MCP-1 production in isolated AM. We found that experimental depletion of AM 
      attenuated the chronic hypoxia-induced increase in mean pulmonary arterial 
      pressure, but did not affect the serum MCP-1 concentrations. Furthermore, the 
      MCP-1 production by AM in vitro was unaffected by hypoxia. Thus we conclude that 
      AM play a significant role in the mechanism of HPH, but MCP-1 release from these 
      cells is most likely not involved in this process. The increase of MCP-1 
      accompanying the development of HPH probably originates from other sources than 
      AM.
FAU - Zaloudikova, M
AU  - Zaloudikova M
AD  - Department of Pathophysiology, Second Faculty of Medicine, Charles University, 
      Prague, Czech Republic. marie.zaloudikova@lfmotol.cuni.cz.
FAU - Vytasek, R
AU  - Vytasek R
FAU - Vajnerova, O
AU  - Vajnerova O
FAU - Hnilickova, O
AU  - Hnilickova O
FAU - Vizek, M
AU  - Vizek M
FAU - Hampl, V
AU  - Hampl V
FAU - Herget, J
AU  - Herget J
LA  - eng
PT  - Journal Article
DEP - 20160715
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0813BZ6866 (Clodronic Acid)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/*blood
MH  - Clodronic Acid/therapeutic use
MH  - Hypertension, Pulmonary/*immunology/prevention & control
MH  - Hypoxia/*complications
MH  - Macrophages, Alveolar/*metabolism
MH  - Male
MH  - Rats, Wistar
EDAT- 2016/07/19 06:00
MHDA- 2017/04/04 06:00
CRDT- 2016/07/19 06:00
PHST- 2016/07/19 06:00 [pubmed]
PHST- 2017/04/04 06:00 [medline]
PHST- 2016/07/19 06:00 [entrez]
AID - 933187 [pii]
AID - 10.33549/physiolres.933187 [doi]
PST - ppublish
SO  - Physiol Res. 2016 Nov 23;65(5):763-768. doi: 10.33549/physiolres.933187. Epub 
      2016 Jul 15.