PMID- 27429585
OWN - NLM
STAT- MEDLINE
DCOM- 20170417
LR  - 20220330
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 13
IP  - 7
DP  - 2016
TI  - Interdependencies among Selected Pro-Inflammatory Markers of Endothelial 
      Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism 
      Disturbance in Obese Women.
PG  - 490-9
LID - 10.7150/ijms.14110 [doi]
AB  - BACKGROUND: Currently increasing importance is attributed to the inflammatory 
      process as a crucial factor responsible for the progressive damage to vascular 
      walls and progression of atherosclerosis in obese people. We have studied the 
      relationship between clinical and biochemical parameters and C-peptide and 
      anti-inflammatory IL-10, as well as selected markers of inflammation and 
      endothelial dysfunction such as: CCL2, CRP, sICAM-1, sVCAM-1 and E-selectin in 
      obese women with various degree of glucose metabolism disturbance. MATERIAL AND 
      METHODS: The studied group consisted of 61 obese women, and 20 normal weight, 
      healthy volunteers. Obese patients were spited in subgroups based on the degree 
      of glucose metabolism disorder. Serum samples were analyzed using ELISA kits. 
      RESULTS: Increased concentrations of sICAM-1, sVCAM-1, E-selectin, CCL2 and CRP 
      were found in all obese groups compared to the normal weight subjects. In 
      patients with Type 2 diabetes mellitus (T2DM) parameters characterizing the 
      degree of obesity significantly positively correlated with levels of CRP and 
      CCL2. Significant relationships were found between levels of glucose and 
      sICAM-1and also E-selectin and HOMA-IR. C-peptide levels are positively 
      associated with CCL2, E-selectin, triglycerides levels, and inversely with IL-10 
      levels in newly diagnosed T2DM group (p<0.05). Concentrations of IL-10 correlated 
      negatively with E-selectin, CCL2, C-peptide levels, and HOMA-IR in T2DM group 
      (p<0.05). CONCLUSION: Disturbed lipid and carbohydrate metabolism are manifested 
      by enhanced inflammation and endothelial dysfunction in patients with simply 
      obesity. These disturbances are associates with an increase of adhesion 
      molecules. The results suggest the probable active participation of higher 
      concentrations of C-peptide in the intensification of inflammatory and 
      atherogenic processes in obese patients with type 2 diabetes. In patients with 
      obesity and type 2 diabetes, altered serum concentrations of Il-10 seems to be 
      dependent on the degree of insulin resistance and proinflammatory status.
FAU - Janowska, Joanna
AU  - Janowska J
AD  - 1. Department of Pathophysiology, Faculty of Medicine, Medical University of 
      Silesia, Katowice, Poland.
FAU - Chudek, Jerzy
AU  - Chudek J
AD  - 1. Department of Pathophysiology, Faculty of Medicine, Medical University of 
      Silesia, Katowice, Poland.
FAU - Olszanecka-Glinianowicz, Magdalena
AU  - Olszanecka-Glinianowicz M
AD  - 2. Health Promotion and Obesity Management Unit, Department of Pathophysiology, 
      Faculty of Medicine, Medical University of Silesia, Katowice, Poland.
FAU - Semik-Grabarczyk, Elzbieta
AU  - Semik-Grabarczyk E
AD  - 3. Department of Internal, Autoimmune and Metabolic Diseases, Faculty of 
      Medicine, Medical University of Silesia, Poland.
FAU - Zahorska-Markiewicz, Barbara
AU  - Zahorska-Markiewicz B
AD  - 5. Outpatient Clinic of Obesity and Metabolic Diseases "Waga", Katowice, Poland.
LA  - eng
PT  - Journal Article
DEP - 20160625
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - 0 (Biomarkers)
RN  - 0 (C-Peptide)
RN  - 0 (Chemokine CCL2)
RN  - 0 (E-Selectin)
RN  - 0 (Triglycerides)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 130068-27-8 (Interleukin-10)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Biomarkers/*blood
MH  - C-Peptide/*blood
MH  - Chemokine CCL2/blood
MH  - Diabetes Mellitus, Type 2/blood
MH  - E-Selectin/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glucose/*metabolism
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/blood
MH  - Interleukin-10/*blood
MH  - Obesity/*blood/*immunology
MH  - Triglycerides/blood
MH  - Vascular Cell Adhesion Molecule-1/blood
PMC - PMC4946119
OTO - NOTNLM
OT  - C-peptide
OT  - Obesity
OT  - adhesion molecules
OT  - chemokine (C-C motif) ligand 2
OT  - endothelial dysfunction
OT  - glucose metabolism disturbance
OT  - interleukin-10.
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2016/07/20 06:00
MHDA- 2017/04/18 06:00
PMCR- 2016/01/01
CRDT- 2016/07/19 06:00
PHST- 2015/10/12 00:00 [received]
PHST- 2016/04/02 00:00 [accepted]
PHST- 2016/07/19 06:00 [entrez]
PHST- 2016/07/20 06:00 [pubmed]
PHST- 2017/04/18 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - ijmsv13p0490 [pii]
AID - 10.7150/ijms.14110 [doi]
PST - epublish
SO  - Int J Med Sci. 2016 Jun 25;13(7):490-9. doi: 10.7150/ijms.14110. eCollection 
      2016.