PMID- 27430331 OWN - NLM STAT- MEDLINE DCOM- 20171212 LR - 20240117 IS - 1532-429X (Electronic) IS - 1097-6647 (Print) IS - 1097-6647 (Linking) VI - 18 IP - 1 DP - 2016 Jul 18 TI - Scar quantification by cardiovascular magnetic resonance as an independent predictor of long-term survival in patients with ischemic heart failure treated by coronary artery bypass graft surgery. PG - 45 LID - 10.1186/s12968-016-0265-y [doi] LID - 45 AB - BACKGROUND: Scar burden by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) is associated with functional recovery after coronary artery bypass surgery (CABG). There is limited data on long-term mortality after CABG based on left ventricular (LV) scar burden. METHODS: Patients who underwent LGE CMR between January 2003 and February 2010 within 1 month prior to CABG were included. A standard 16 segment model was used for scar quantification. A score of 1 for no scar, 2 for 50 % transmurality was assigned for each segment. LV scar score (LVSS) defined as the sum of segment scores divided by 16. All-cause mortality was ascertained by social security death index. RESULTS: One hundred ninety-six patients met the inclusion criteria. 185 CMR studies were available. History of prior MI was present in 64 % and prior CABG in 5.4 % of patients. Scar was present in 72 % of patients and median LVEF was 38 %. Over a median follow up of 8.3 years, there were 64 deaths (34.6 %). There was no statistically significant difference in mortality between Scar and No-scar groups (37 % versus 29 %). In the group with scar, a lower scar burden (defined either < 4 segments with scar or based on LVSS) was independently associated with increased survival. CONCLUSION: In patients undergoing surgical revascularization, scar burden is negatively associated with survival in patients with scar. However, there is no difference in survival based on presence or absence of scar alone. CMR prior to CABG adds additional prognostic information. FAU - Kancharla, Krishna AU - Kancharla K AD - Department of cardiology, Mayo Clinic, Rochester, 55905, MN, USA. krish.kancharla@gmail.com. FAU - Weissman, Gaby AU - Weissman G AD - Division of Cardiology, MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC, USA. AD - Georgetown University, Washington, DC, USA. FAU - Elagha, Abdalla A AU - Elagha AA AD - Department of cardiology, Cairo University Hospitals, Cairo, Egypt. AD - Translational Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA. FAU - Kancherla, Kalyan AU - Kancherla K AD - MedStar Health Research Institute, Washington, DC, USA. AD - Howard University Hospital, Washington, DC, USA. FAU - Samineni, Swetha AU - Samineni S AD - Mayo Clinic Health Systems, Austin, MN, USA. FAU - Hill, Peter C AU - Hill PC AD - Department of Cardiac Surgery, MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC, USA. FAU - Boyce, Steven AU - Boyce S AD - Georgetown University, Washington, DC, USA. AD - Department of Cardiac Surgery, MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC, USA. FAU - Fuisz, Anthon R AU - Fuisz AR AD - Division of Cardiology, Westchester Medical Center, Valhalla, New York, USA. LA - eng PT - Journal Article PT - Observational Study DEP - 20160718 PL - England TA - J Cardiovasc Magn Reson JT - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JID - 9815616 RN - 0 (Contrast Media) SB - IM MH - Aged MH - Cardiomyopathies/*diagnostic imaging/mortality/physiopathology MH - Cicatrix/*diagnostic imaging/mortality/physiopathology MH - Contrast Media/administration & dosage MH - *Coronary Artery Bypass/adverse effects/mortality MH - Coronary Artery Disease/diagnostic imaging/mortality/*surgery MH - Databases, Factual MH - Female MH - Heart Failure/*diagnostic imaging/mortality/physiopathology MH - Humans MH - Kaplan-Meier Estimate MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - Myocardial Infarction/*diagnostic imaging/mortality/physiopathology MH - Myocardium/*pathology MH - Predictive Value of Tests MH - Proportional Hazards Models MH - Recovery of Function MH - Retrospective Studies MH - Risk Factors MH - Stroke Volume MH - Time Factors MH - Treatment Outcome MH - Ventricular Function, Left PMC - PMC4950709 OTO - NOTNLM OT - CABG OT - Cardiovascular magnetic resonance OT - Ischemic cardiomyopathy OT - Mortality OT - Scar EDAT- 2016/07/20 06:00 MHDA- 2017/12/13 06:00 PMCR- 2016/07/18 CRDT- 2016/07/20 06:00 PHST- 2016/01/29 00:00 [received] PHST- 2016/07/01 00:00 [accepted] PHST- 2016/07/20 06:00 [entrez] PHST- 2016/07/20 06:00 [pubmed] PHST- 2017/12/13 06:00 [medline] PHST- 2016/07/18 00:00 [pmc-release] AID - S1097-6647(23)00986-9 [pii] AID - 265 [pii] AID - 10.1186/s12968-016-0265-y [doi] PST - epublish SO - J Cardiovasc Magn Reson. 2016 Jul 18;18(1):45. doi: 10.1186/s12968-016-0265-y.