PMID- 27430331
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 18
IP  - 1
DP  - 2016 Jul 18
TI  - Scar quantification by cardiovascular magnetic resonance as an independent 
      predictor of long-term survival in patients with ischemic heart failure treated 
      by coronary artery bypass graft surgery.
PG  - 45
LID - 10.1186/s12968-016-0265-y [doi]
LID - 45
AB  - BACKGROUND: Scar burden by late gadolinium enhancement (LGE) cardiovascular 
      magnetic resonance (CMR) is associated with functional recovery after coronary 
      artery bypass surgery (CABG). There is limited data on long-term mortality after 
      CABG based on left ventricular (LV) scar burden. METHODS: Patients who underwent 
      LGE CMR between January 2003 and February 2010 within 1 month prior to CABG were 
      included. A standard 16 segment model was used for scar quantification. A score 
      of 1 for no scar, 2 for </= 50 % and 3 for > 50 % transmurality was assigned for 
      each segment. LV scar score (LVSS) defined as the sum of segment scores divided 
      by 16. All-cause mortality was ascertained by social security death index. 
      RESULTS: One hundred ninety-six patients met the inclusion criteria. 185 CMR 
      studies were available. History of prior MI was present in 64 % and prior CABG in 
      5.4 % of patients. Scar was present in 72 % of patients and median LVEF was 38 %. 
      Over a median follow up of 8.3 years, there were 64 deaths (34.6 %). There was no 
      statistically significant difference in mortality between Scar and No-scar groups 
      (37 % versus 29 %). In the group with scar, a lower scar burden (defined 
      either < 4 segments with scar or based on LVSS) was independently associated with 
      increased survival. CONCLUSION: In patients undergoing surgical 
      revascularization, scar burden is negatively associated with survival in patients 
      with scar. However, there is no difference in survival based on presence or 
      absence of scar alone. CMR prior to CABG adds additional prognostic information.
FAU - Kancharla, Krishna
AU  - Kancharla K
AD  - Department of cardiology, Mayo Clinic, Rochester, 55905, MN, USA. 
      krish.kancharla@gmail.com.
FAU - Weissman, Gaby
AU  - Weissman G
AD  - Division of Cardiology, MedStar Heart and Vascular Institute, MedStar Washington 
      Hospital Center, Washington, DC, USA.
AD  - Georgetown University, Washington, DC, USA.
FAU - Elagha, Abdalla A
AU  - Elagha AA
AD  - Department of cardiology, Cairo University Hospitals, Cairo, Egypt.
AD  - Translational Medicine Branch, National Heart, Lung, and Blood Institute, 
      Bethesda, MD, USA.
FAU - Kancherla, Kalyan
AU  - Kancherla K
AD  - MedStar Health Research Institute, Washington, DC, USA.
AD  - Howard University Hospital, Washington, DC, USA.
FAU - Samineni, Swetha
AU  - Samineni S
AD  - Mayo Clinic Health Systems, Austin, MN, USA.
FAU - Hill, Peter C
AU  - Hill PC
AD  - Department of Cardiac Surgery, MedStar Heart and Vascular Institute, MedStar 
      Washington Hospital Center, Washington, DC, USA.
FAU - Boyce, Steven
AU  - Boyce S
AD  - Georgetown University, Washington, DC, USA.
AD  - Department of Cardiac Surgery, MedStar Heart and Vascular Institute, MedStar 
      Washington Hospital Center, Washington, DC, USA.
FAU - Fuisz, Anthon R
AU  - Fuisz AR
AD  - Division of Cardiology, Westchester Medical Center, Valhalla, New York, USA.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20160718
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
SB  - IM
MH  - Aged
MH  - Cardiomyopathies/*diagnostic imaging/mortality/physiopathology
MH  - Cicatrix/*diagnostic imaging/mortality/physiopathology
MH  - Contrast Media/administration & dosage
MH  - *Coronary Artery Bypass/adverse effects/mortality
MH  - Coronary Artery Disease/diagnostic imaging/mortality/*surgery
MH  - Databases, Factual
MH  - Female
MH  - Heart Failure/*diagnostic imaging/mortality/physiopathology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnostic imaging/mortality/physiopathology
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - Recovery of Function
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Function, Left
PMC - PMC4950709
OTO - NOTNLM
OT  - CABG
OT  - Cardiovascular magnetic resonance
OT  - Ischemic cardiomyopathy
OT  - Mortality
OT  - Scar
EDAT- 2016/07/20 06:00
MHDA- 2017/12/13 06:00
PMCR- 2016/07/18
CRDT- 2016/07/20 06:00
PHST- 2016/01/29 00:00 [received]
PHST- 2016/07/01 00:00 [accepted]
PHST- 2016/07/20 06:00 [entrez]
PHST- 2016/07/20 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
PHST- 2016/07/18 00:00 [pmc-release]
AID - S1097-6647(23)00986-9 [pii]
AID - 265 [pii]
AID - 10.1186/s12968-016-0265-y [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2016 Jul 18;18(1):45. doi: 10.1186/s12968-016-0265-y.