PMID- 27431398
OWN - NLM
STAT- MEDLINE
DCOM- 20170711
LR  - 20231117
IS  - 1866-3370 (Print)
IS  - 1866-3370 (Linking)
VI  - 32
DP  - 2017
TI  - Reinforcing Effects of Cathinone NPS in the Intravenous Drug Self-Administration 
      Paradigm.
PG  - 133-143
LID - 10.1007/7854_2016_33 [doi]
AB  - Since the mid- to late 2000s, there has been a dramatic rise in the use and abuse 
      of synthetic derivatives of cathinone, a stimulant alkaloid found in the African 
      shrub Catha edulis. Cathinone novel psychoactive substances (NPS), also referred 
      to as synthetic cathinones or "bath salt"-type drugs, have gained popularity 
      among drug users due to their potency, low cost, ease of procurement, and diverse 
      array of evolving chemical structures. While the ability of cathinone NPS to 
      produce psychotomimetic effects, multiple organ system toxicity, and death in 
      humans is well documented, there has been limited scientific investigation into 
      the reinforcing effects and abuse liability of these drugs. In this chapter, we 
      will summarize the existing literature on the reinforcing effects of cathinone 
      NPS in rodents using the intravenous self-administration (IVSA) paradigm. We will 
      also compare the ability of cathinone NPS to serve as reinforcers to that of 
      classical psychostimulants such as cocaine, methamphetamine, and 
      methylenedioxymethamphetamine (MDMA). The chapter will conclude with a summary 
      and indications for future avenues of research on cathinone NPS.
FAU - Watterson, Lucas R
AU  - Watterson LR
AD  - Department of Psychology, Arizona State University, 871104, Tempe, AZ, 85287, 
      USA.
FAU - Olive, M Foster
AU  - Olive MF
AD  - Department of Psychology, Arizona State University, 871104, Tempe, AZ, 85287, 
      USA. foster.olive@asu.edu.
LA  - eng
GR  - R01 DA025606/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - Germany
TA  - Curr Top Behav Neurosci
JT  - Current topics in behavioral neurosciences
JID - 101535383
RN  - 0 (Alkaloids)
RN  - 0 (Benzodioxoles)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Psychotropic Drugs)
RN  - 0 (Pyrrolidines)
RN  - 44RAL3456C (Methamphetamine)
RN  - 540EI4406J (cathinone)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - 0 (Synthetic Cathinone)
SB  - IM
MH  - Administration, Intravenous
MH  - Alkaloids/*pharmacology
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Benzodioxoles/pharmacology
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Cocaine/pharmacology
MH  - Conditioning, Operant
MH  - Methamphetamine/pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
MH  - Psychotropic Drugs/*pharmacology
MH  - Pyrrolidines/pharmacology
MH  - Rats
MH  - *Reinforcement, Psychology
MH  - *Self Administration
MH  - Synthetic Cathinone
OTO - NOTNLM
OT  - Animal model
OT  - Cathinone
OT  - Intravenous self-administration
OT  - Operant conditioning
OT  - Reinforcement
EDAT- 2016/07/20 06:00
MHDA- 2017/07/14 06:00
CRDT- 2016/07/20 06:00
PHST- 2016/07/20 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
PHST- 2016/07/20 06:00 [entrez]
AID - 10.1007/7854_2016_33 [doi]
PST - ppublish
SO  - Curr Top Behav Neurosci. 2017;32:133-143. doi: 10.1007/7854_2016_33.