PMID- 27434892
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20180110
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
VI  - 47
IP  - 7
DP  - 2016 Jul 1
TI  - Choroidal Morphology and Vascular Analysis in Eyes With Neovascular Age-Related 
      Macular Degeneration Using Spectral-Domain Optical Coherence Tomography.
PG  - 618-25
LID - 10.3928/23258160-20160707-02 [doi]
AB  - BACKGROUND AND OBJECTIVE: To describe morphology and vascular layer thickness of 
      the choroid in eyes with neovascular age-related macular degeneration (AMD) using 
      spectral-domain optical coherence tomography (SD-OCT). PATIENTS AND METHODS: 
      Cross-sectional, retrospective analysis of 15 eyes with neovascular AMD and 11 
      healthy age-matched eyes that underwent single horizontal, high-definition raster 
      line imaging using high-definition SD-OCT. Two independent graders assessed 
      choroid morphology and measured the thickness of individual vascular layers of 
      the choroid beneath the fovea. RESULTS: Normal concave choroidal contour was 
      found in 13.3% of eyes with neovascular AMD and 100% of healthy eyes. The 
      thickest point of the choroid was located beneath the foveal center in 20% of 
      eyes and focal thinning was observed in 40% of eyes with neovascular AMD, 
      compared to 91% and 0% of healthy eyes, respectively. Subfoveal total choroidal 
      thickness, large choroidal vessel layer thickness, and the medium choroidal 
      vessel/choriocapillaris layer thickness were reduced in eyes with neovascular AMD 
      compared to healthy eyes (205.7 microm +/- 17.08 microm versus 281.3 microm +/- 19.29 microm, P = 
      .007; 174.1 microm +/- 16.34 microm versus 244.5 microm +/- 19.51 microm, P = .01; and 31.53 microm +/- 
      3.67 microm verus 51.9 microm +/- 1.94 microm, P = .0002, respectively). CONCLUSION: Choroidal 
      morphology is altered in eyes with neovascular AMD as assessed on SDOCT. 
      Choroidal thinning in neovascular AMD involves all its vascular layers. These 
      morphological and vascular changes may have clinical implications in the 
      diagnosis and monitoring of eyes with neovascular AMD. [Ophthalmic Surg Lasers 
      Imaging Retina. 2016;47:618-625.].
CI  - Copyright 2016, SLACK Incorporated.
FAU - Legocki, Alex T
AU  - Legocki AT
FAU - Adhi, Mehreen
AU  - Adhi M
FAU - Weber, Marissa L
AU  - Weber ML
FAU - Duker, Jay S
AU  - Duker JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
SB  - IM
MH  - Aged
MH  - Choroid/*blood supply
MH  - Choroidal Neovascularization/*diagnosis/etiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Retinal Vessels/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
MH  - Wet Macular Degeneration/*complications/diagnosis
EDAT- 2016/07/21 06:00
MHDA- 2017/07/01 06:00
CRDT- 2016/07/20 06:00
PHST- 2015/12/08 00:00 [received]
PHST- 2016/04/22 00:00 [accepted]
PHST- 2016/07/20 06:00 [entrez]
PHST- 2016/07/21 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
AID - 10.3928/23258160-20160707-02 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2016 Jul 1;47(7):618-25. doi: 
      10.3928/23258160-20160707-02.