PMID- 27435287
OWN - NLM
STAT- MEDLINE
DCOM- 20170417
LR  - 20181113
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Linking)
VI  - 37
IP  - 4
DP  - 2017 May
TI  - The Effects of Astilbin on Cognitive Impairments in a Transgenic Mouse Model of 
      Alzheimer's Disease.
PG  - 695-706
LID - 10.1007/s10571-016-0405-9 [doi]
AB  - Bioflavonoids are being utilised as neuroprotectants in the treatment of various 
      neurological disorders, including Alzheimer's disease (AD). Astilbin, a 
      bioflavanoid, has been reported to have potent neuroprotective effects, but its 
      preventive effects on amyloid-beta (Abeta)-induced, Alzheimer's disease-related, 
      cognitive impairment, and the underlying mechanisms of these effects have not 
      been well characterised. Five-month-old APPswe/PS1dE9 transgenic mice were 
      randomly assigned to a vehicle group and two astilbin (either 20 or 40 mg/kg per 
      day, intraperitoneally) groups. After 8 weeks of treatment, we observed 
      beneficial effects of astilbin (40 mg/kg per day), including lessening learning 
      and memory deficits and reducing plaque burden and Abeta levels. Furthermore, the 
      expressions of both the cAMP responsive element-binding protein (CREB) and 
      brain-derived neurotrophic factor (BDNF) were significantly increased and the 
      disturbance of AKT/GSK-3beta signalling pathway was markedly ameliorated in the 
      hippocampus of astilbin-treated (40 mg/kg per day) group. Our data suggest that 
      astilbin might be a potential therapeutic agent against AD.
FAU - Wang, Dongmei
AU  - Wang D
AD  - Department of Pathogen Biology, Medical College, Henan University of Science and 
      Technology, Building 6, Anhui, Jianxi District, Luoyang, 471003, China. 
      wdmzgadyx@hotmail.com.
FAU - Li, Sanqiang
AU  - Li S
AD  - Department of Biochemistry and Molecular Biology, Medical College, Henan 
      University of Science and Technology, Luoyang, China.
FAU - Chen, Jing
AU  - Chen J
AD  - Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, 
      Jingba Road 2, Zhengzhou, 450014, China.
FAU - Liu, Ling
AU  - Liu L
AD  - Department of Pathogen Biology, Medical College, Henan University of Science and 
      Technology, Building 6, Anhui, Jianxi District, Luoyang, 471003, China.
FAU - Zhu, Xiaoying
AU  - Zhu X
AD  - Department of Pathogen Biology, Medical College, Henan University of Science and 
      Technology, Building 6, Anhui, Jianxi District, Luoyang, 471003, China.
LA  - eng
PT  - Journal Article
DEP - 20160719
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Flavonols)
RN  - 29838-67-3 (astilbin)
SB  - IM
MH  - Alzheimer Disease/drug therapy/metabolism/*physiopathology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognitive Dysfunction/drug therapy/metabolism/*physiopathology
MH  - Disease Models, Animal
MH  - Flavonols/*pharmacology
MH  - Hippocampus/drug effects/metabolism
MH  - Mice
MH  - Mice, Transgenic
OTO - NOTNLM
OT  - APPswe/PS1dE9 mice
OT  - Astilbin
OT  - CREB/BDNF pathway
OT  - Cognitive ability
EDAT- 2016/07/21 06:00
MHDA- 2017/04/18 06:00
CRDT- 2016/07/21 06:00
PHST- 2016/04/26 00:00 [received]
PHST- 2016/07/06 00:00 [accepted]
PHST- 2016/07/21 06:00 [pubmed]
PHST- 2017/04/18 06:00 [medline]
PHST- 2016/07/21 06:00 [entrez]
AID - 10.1007/s10571-016-0405-9 [pii]
AID - 10.1007/s10571-016-0405-9 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2017 May;37(4):695-706. doi: 10.1007/s10571-016-0405-9. Epub 
      2016 Jul 19.