PMID- 2743846
OWN - NLM
STAT- MEDLINE
DCOM- 19890816
LR  - 20190721
IS  - 0163-2116 (Print)
IS  - 0163-2116 (Linking)
VI  - 34
IP  - 7
DP  - 1989 Jul
TI  - The hypertensive lower esophageal sphincter. Manometric and clinical aspects.
PG  - 1063-7
AB  - Controversy exists as to whether the hypertensive lower esophageal sphincter 
      (HLES) represents a clinical motility disorder of the esophagus or is merely the 
      right-sided expression of a normal distribution curve. In the present study we 
      describe 16 patients with HLES, defined as a lower esophageal sphincter (LES) 
      pressure of greater than or equal to 40 mm Hg (mean + 3 SD of controls) with 
      normal peristalsis. All of the patients suffered from chest pain and nine from 
      dysphagia. Delayed bolus transit at the gastroesophageal junction was 
      demonstrated in four patients by radiography. Manometric studies showed that 
      during swallowing the LES residual pressures were significantly greater (9.2 +/- 
      5.0 mm Hg) than observed in normal controls (1.8 +/- 2.2 mmHg) (mean +/- 1 SD). 
      However, the percent LES relaxation in patients did not differ significantly from 
      controls. Clinical improvement was associated with pharmacological or mechanical 
      reduction of resting LES pressure with an accompanying fall in the nadir 
      pressure. These observations suggest that HLES may have clinical and 
      pathophysiological significance and that evidence for the entity should be sought 
      during manometric studies in the clinical laboratory.
FAU - Freidin, N
AU  - Freidin N
AD  - Department of Internal Medicine, University of Virginia Health Sciences Center, 
      Charlottesville 22908.
FAU - Traube, M
AU  - Traube M
FAU - Mittal, R K
AU  - Mittal RK
FAU - McCallum, R W
AU  - McCallum RW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
SB  - IM
CIN - Dig Dis Sci. 1990 Feb;35(2):281. PMID: 2302989
MH  - Adult
MH  - Chest Pain/etiology
MH  - Deglutition
MH  - Deglutition Disorders/etiology
MH  - Esophageal Diseases/physiopathology
MH  - Esophagogastric Junction/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Manometry/methods
MH  - Middle Aged
MH  - Pressure
EDAT- 1989/07/01 00:00
MHDA- 1989/07/01 00:01
CRDT- 1989/07/01 00:00
PHST- 1989/07/01 00:00 [pubmed]
PHST- 1989/07/01 00:01 [medline]
PHST- 1989/07/01 00:00 [entrez]
AID - 10.1007/BF01536375 [doi]
PST - ppublish
SO  - Dig Dis Sci. 1989 Jul;34(7):1063-7. doi: 10.1007/BF01536375.