PMID- 27440214
OWN - NLM
STAT- MEDLINE
DCOM- 20180628
LR  - 20180628
IS  - 2041-1626 (Electronic)
IS  - 2041-1618 (Linking)
VI  - 8
IP  - 3
DP  - 2017 Aug
TI  - Association among interleukin-6 gene polymorphisms, type 2 diabetes mellitus, and 
      chronic periodontitis: a pilot study.
LID - 10.1111/jicd.12230 [doi]
AB  - AIM: The purpose of this pilot study was to determine the association between 
      single nucleotide polymorphisms (-174 G>C) in the interleukin-6 (IL-6) gene with 
      chronic periodontitis (CP) and type 2 diabetes mellitus (T2DM) in south Indian 
      population. METHODS: Genomic DNA was obtained from the white blood cells of 30 
      patients with T2DM, 30 patients with CP, 30 patients with T2DM with CP, and 30 
      controls. DNA was amplified using polymerase chain reaction with specific primers 
      flanking the locus -174 of the IL-6 gene and further genotyped using the 
      restriction fragment length polymorphism method. The genotype distribution and 
      allele frequencies between the study groups were determined using chi(2) -test. The 
      relative risk was estimated with a 95% confidence interval. RESULTS: The CP group 
      (26.7%) displayed a greater percentage of GC genotype (P = 0.026) when compared 
      to the control group (3.3%). A statistically-significant difference in the allele 
      frequencies was found between the control and CP group with the C-allele 
      frequency being greater (0.13) in the CP group than normal controls (0.02). 
      CONCLUSION: The GC genotype was found to be the risk genotype and the C allele 
      was found to be the risk allele for the development of CP.
CI  - (c) 2016 John Wiley & Sons Australia, Ltd.
FAU - Kavitha, Loganathan
AU  - Kavitha L
AD  - Department of Oral and Maxillofacial Pathology, Ragas Dental College and 
      Hospital, Chennai, India.
FAU - Vijayshree Priyadharshini, Jayaseelan
AU  - Vijayshree Priyadharshini J
AD  - Central Research Laboratory, Meenakshi Ammal Dental College and Hospital, 
      Chennai, India.
FAU - Sivapathasundharam, Balasundaram
AU  - Sivapathasundharam B
AD  - Department of Oral Pathology and Microbiology, Meenakshi Ammal Dental College and 
      Hospital, Chennai, India.
LA  - eng
PT  - Journal Article
DEP - 20160721
PL  - Australia
TA  - J Investig Clin Dent
JT  - Journal of investigative and clinical dentistry
JID - 101524471
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chronic Periodontitis/*genetics
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Gene Frequency
MH  - Humans
MH  - India
MH  - Interleukin-6/*genetics
MH  - Middle Aged
MH  - Pilot Projects
MH  - *Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - chronic periodontitis
OT  - interleukin-6 gene
OT  - polymerase chain reaction
OT  - single nucleotide polymorphism
OT  - type 2 diabetes mellitus
EDAT- 2016/07/22 06:00
MHDA- 2018/06/29 06:00
CRDT- 2016/07/22 06:00
PHST- 2015/10/29 00:00 [received]
PHST- 2016/05/25 00:00 [accepted]
PHST- 2016/07/22 06:00 [pubmed]
PHST- 2018/06/29 06:00 [medline]
PHST- 2016/07/22 06:00 [entrez]
AID - 10.1111/jicd.12230 [doi]
PST - ppublish
SO  - J Investig Clin Dent. 2017 Aug;8(3). doi: 10.1111/jicd.12230. Epub 2016 Jul 21.