PMID- 27440697
OWN - NLM
STAT- MEDLINE
DCOM- 20160913
LR  - 20220408
IS  - 0964-7058 (Print)
IS  - 0964-7058 (Linking)
VI  - 25
IP  - 3
DP  - 2016
TI  - The genetic polymorphisms in vitamin D receptor and the risk of type 2 diabetes 
      mellitus: an updated meta-analysis.
PG  - 614-24
LID - 10.6133/apjcn.092015.12 [doi]
AB  - BACKGROUND AND OBJECTIVES: Vitamin D receptor (VDR) genetic polymorphisms are 
      considered to be associated with type 2 diabetes mellitus (T2DM), but this is 
      inconclusive. The aim of this study is to quantify the association between 
      polymorphisms of BsmI and FokI in the VDR gene and T2DM risk through literature 
      review. METHODS AND STUDY DESIGN: Original articles published from 1999 to June 
      2014 were discovered through PubMed, ISI Web of Science, China National Knowledge 
      Infrastructure, Chinese Wanfang Database, and the Chinese Biomedical Literature 
      Database. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were 
      calculated with software STATA version 12.0. RESULTS: Twenty-three articles 
      containing 30 case-control studies were included. The association between the 
      BsmI polymorphism and T2DM was weak in two genetic models (Bb vs bb and BB+Bb vs 
      bb). The subgroup analysis showed that this association was only found in the 
      studies with a small sample size (<200). A strong association between FokI 
      polymorphism and T2DM indicated that this gene polymorphism was possibly a risk 
      factor for T2DM (ff vs FF: OR=1.57, 95% CI: 1.28-1.93, p<0.001; Ff vs FF: 
      OR=1.54, 95% CI: 1.31-1.81, p<0.001; ff+Ff vs FF: OR=1.57, 95% CI: 1.35-1.83, 
      p<0.001), especially in Chinese populations. CONCLUSION: More reliable 
      conclusions about associations between VDR genetic polymorphisms and T2DM will 
      depend on studies with larger sample size and by ethnicity.
FAU - Yu, Fei
AU  - Yu F
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Cui, Ling Ling
AU  - Cui LL
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Li, Xing
AU  - Li X
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Wang, Chong Jian
AU  - Wang CJ
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Ba, Yue
AU  - Ba Y
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Wang, Ling
AU  - Wang L
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Li, Jing
AU  - Li J
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Li, Chao
AU  - Li C
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Dai, Li Ping
AU  - Dai LP
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Li, Wen Jie
AU  - Li WJ
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China. Email: lwj@zzu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Asia Pac J Clin Nutr
JT  - Asia Pacific journal of clinical nutrition
JID - 9440304
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (VDR protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Genetic/*genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Publication Bias
MH  - Receptors, Calcitriol/*genetics
EDAT- 2016/07/22 06:00
MHDA- 2016/09/14 06:00
CRDT- 2016/07/22 06:00
PHST- 2016/07/22 06:00 [entrez]
PHST- 2016/07/22 06:00 [pubmed]
PHST- 2016/09/14 06:00 [medline]
AID - 10.6133/apjcn.092015.12 [doi]
PST - ppublish
SO  - Asia Pac J Clin Nutr. 2016;25(3):614-24. doi: 10.6133/apjcn.092015.12.