PMID- 27442085
OWN - NLM
STAT- MEDLINE
DCOM- 20180420
LR  - 20190318
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 87
IP  - 11
DP  - 2016 Nov
TI  - Efficacy of Subgingivally Delivered 1.2% Atorvastatin in the Treatment of Chronic 
      Periodontitis in Patients With Type 2 Diabetes Mellitus: A Randomized Controlled 
      Clinical Trial.
PG  - 1278-1285
AB  - BACKGROUND: The present study was designed to evaluate effectiveness of 1.2% 
      atorvastatin (ATV) gel, as an adjunct to scaling and root planing (SRP) in the 
      treatment of intrabony defects in chronic periodontitis (CP) in patients with 
      type 2 diabetes mellitus (t2DM). METHODS: Seventy-five patients were categorized 
      into two treatment groups: 1) SRP plus 1.2% ATV and 2) SRP plus placebo. Clinical 
      parameters including modified sulcus bleeding index, probing depth (PD), and 
      relative attachment level (RAL) were recorded at baseline and 3, 6, and 9 months. 
      Percentage radiographic defect depth reduction was evaluated using computer-aided 
      software at baseline and 6 and 9 months. RESULTS: Mean PD reduction and mean RAL 
      gain was greater in the ATV group than the placebo group at 3, 6, and 9 months. 
      Furthermore, ATV group sites presented with a significantly greater percentage of 
      radiographic defect depth reduction at 6 and 9 months. CONCLUSION: Locally 
      delivered ATV was found to be effective in treatment of intrabony defects in CP 
      in patients with t2DM.
FAU - Kumari, Minal
AU  - Kumari M
AD  - Department of Periodontics, Vydehi Institute of Dental Sciences and Research 
      Centre, Bangalore, India.
FAU - Martande, Santosh S
AU  - Martande SS
AD  - Department of Periodontics, Dr. D.Y. Patil Dental College and Hospital, Pune, 
      India.
FAU - Pradeep, A R
AU  - Pradeep AR
AD  - Department of Periodontics, Government Dental College and Research Institute, 
      Bangalore, India.
FAU - Naik, Savitha B
AU  - Naik SB
AD  - Department of Conservative Dentistry and Endodontics, Government Dental College 
      and Research Institute.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160721
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - A0JWA85V8F (Atorvastatin)
SB  - IM
MH  - Alveolar Bone Loss
MH  - Anti-Bacterial Agents
MH  - Atorvastatin/*therapeutic use
MH  - Chronic Periodontitis/complications/*drug therapy
MH  - Dental Scaling
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Follow-Up Studies
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
MH  - Periodontal Index
MH  - Root Planing
OTO - NOTNLM
OT  - *Atorvastatin calcium
OT  - *bone regeneration
OT  - *chronic periodontitis
OT  - *clinical trial
OT  - *diabetes mellitus
OT  - *radiography, dental
EDAT- 2016/10/25 06:00
MHDA- 2018/04/21 06:00
CRDT- 2016/07/22 06:00
PHST- 2016/10/25 06:00 [pubmed]
PHST- 2018/04/21 06:00 [medline]
PHST- 2016/07/22 06:00 [entrez]
AID - 10.1902/jop.2016.130227 [doi]
PST - ppublish
SO  - J Periodontol. 2016 Nov;87(11):1278-1285. doi: 10.1902/jop.2016.130227. Epub 2016 
      Jul 21.