PMID- 27443169 OWN - NLM STAT- MEDLINE DCOM- 20170629 LR - 20181202 IS - 1573-7225 (Electronic) IS - 0957-5243 (Linking) VI - 27 IP - 9 DP - 2016 Sep TI - Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancer. PG - 1105-15 LID - 10.1007/s10552-016-0788-4 [doi] AB - PURPOSE: Allergy symptoms have been associated with a reduced head and neck cancer (HNC) risk, while elevated blood immunoglobulin E (IgE) levels have been associated with an increased HNC risk. According to the "prophylaxis hypothesis," allergic reaction is the body's way of expelling carcinogens. IgE level may be increased by exposure to environmental carcinogens, including alcohol and cigarette smoke. We hypothesized that individuals with elevated serum IgE without allergy symptoms (i.e., asymptomatic atopic) would have the highest HNC risk. METHODS: A case-control study of HNC (576 cases and 740 controls) was conducted to evaluate the association between allergy symptoms or serum total IgE and HNC risk and the effect modification of allergy symptoms on the association between serum total IgE and HNC risk. RESULTS: Elevated serum total IgE was associated with a significantly increased HNC risk [odds ratio (OR) 1.71, 95 % confidence interval (CI) 1.21-2.42]. Having allergy symptoms was associated with a significantly reduced HNC risk (OR 0.56, 95 % CI 0.43-0.73). Compared to subjects with normal serum total IgE and no allergy symptoms, asymptomatic atopic individuals had a significantly increased HNC risk (OR 2.12, 95 % CI 1.33-3.35). CONCLUSIONS: Our results provided further evidence to support the "prophylaxis hypothesis." Further investigations regarding the immune profiles of asymptomatic atopic individuals may provide additional clues for the biological mechanisms underlying the association between allergy symptoms, IgE, and HNC risk. FAU - Liao, Hsiao-Chen AU - Liao HC AD - Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Wu, Shang-Yin AU - Wu SY AD - Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Ou, Chun-Yen AU - Ou CY AD - Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Hsiao, Jenn-Ren AU - Hsiao JR AD - Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Huang, Jehn-Shyun AU - Huang JS AD - Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Tsai, Sen-Tien AU - Tsai ST AD - Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Huang, Cheng-Chih AU - Huang CC AD - Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Wong, Tung-Yiu AU - Wong TY AD - Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Lee, Wei-Ting AU - Lee WT AD - Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Chen, Ken-Chung AU - Chen KC AD - Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Fang, Sheen-Yie AU - Fang SY AD - Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Wu, Jiunn-Liang AU - Wu JL AD - Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Huang, Tze-Ta AU - Huang TT AD - Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Wu, Yuan-Hua AU - Wu YH AD - Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Hsueh, Wei-Ting AU - Hsueh WT AD - Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Yen, Chia-Jui AU - Yen CJ AD - Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Yang, Ming-Wei AU - Yang MW AD - Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Lin, Forn-Chia AU - Lin FC AD - Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Lai, Yu-Hsuan AU - Lai YH AD - Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Chang, Jang-Yang AU - Chang JY AD - Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Lin, Chen-Lin AU - Lin CL AD - Department of Nursing, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Wang, Yi-Hui AU - Wang YH AD - National Institute of Cancer Research, National Health Research Institutes, 1F No. 367, Sheng-Li Road, Tainan, 70456, Taiwan. FAU - Weng, Ya-Ling AU - Weng YL AD - National Institute of Cancer Research, National Health Research Institutes, 1F No. 367, Sheng-Li Road, Tainan, 70456, Taiwan. FAU - Yang, Han-Chien AU - Yang HC AD - National Institute of Cancer Research, National Health Research Institutes, 1F No. 367, Sheng-Li Road, Tainan, 70456, Taiwan. FAU - Chen, Yu-Shan AU - Chen YS AD - Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 70456, Taiwan. FAU - Chang, Jeffrey S AU - Chang JS AD - National Institute of Cancer Research, National Health Research Institutes, 1F No. 367, Sheng-Li Road, Tainan, 70456, Taiwan. jeffreychang@nhri.org.tw. LA - eng PT - Journal Article DEP - 20160721 PL - Netherlands TA - Cancer Causes Control JT - Cancer causes & control : CCC JID - 9100846 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Case-Control Studies MH - Female MH - Head and Neck Neoplasms/blood/*epidemiology/immunology MH - Humans MH - Hypersensitivity/blood/*epidemiology/immunology MH - Immunoglobulin E/*blood MH - Incidence MH - Male MH - Middle Aged MH - Risk OTO - NOTNLM OT - Allergy OT - Case-control OT - Head and neck cancer OT - Immunoglobulin E EDAT- 2016/07/23 06:00 MHDA- 2017/07/01 06:00 CRDT- 2016/07/23 06:00 PHST- 2016/02/18 00:00 [received] PHST- 2016/07/14 00:00 [accepted] PHST- 2016/07/23 06:00 [entrez] PHST- 2016/07/23 06:00 [pubmed] PHST- 2017/07/01 06:00 [medline] AID - 10.1007/s10552-016-0788-4 [pii] AID - 10.1007/s10552-016-0788-4 [doi] PST - ppublish SO - Cancer Causes Control. 2016 Sep;27(9):1105-15. doi: 10.1007/s10552-016-0788-4. Epub 2016 Jul 21.