PMID- 27443218
OWN - NLM
STAT- MEDLINE
DCOM- 20180122
LR  - 20181113
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Print)
IS  - 0890-6238 (Linking)
VI  - 68
DP  - 2017 Mar
TI  - Chromium VI - Induced developmental toxicity of placenta is mediated through 
      spatiotemporal dysregulation of cell survival and apoptotic proteins.
PG  - 171-190
LID - S0890-6238(16)30263-5 [pii]
LID - 10.1016/j.reprotox.2016.07.006 [doi]
AB  - Environmental contamination with hexavalent chromium (CrVI) is a growing problem 
      both in the U.S and developing countries. CrVI is a heavy-metal endocrine 
      disruptor; women working in Cr industries exhibit an increased incidence of 
      premature abortion and infertility. The current study was designed to understand 
      the mechanism of CrVI toxicity on placental cell survival/death pathways. 
      Pregnant mothers were treated with or without CrVI (50ppmK(2)Cr(2)O(7)) through 
      drinking water from gestational day (GD) 9.5-14.5, and placentas were analyzed on 
      GD 18.5. Results indicated that CrVI increased apoptosis of trophoblasts, 
      vascular endothelium of the metrial glands and yolk sac epithelium through 
      caspase-3 and p53-dependent pathways. CrVI increased apoptosis in labyrinth and 
      basal zones in a caspase-3-independent manner via AIF, and through an 
      ATM-p53-NOXA-PUMA-p27 network. CrVI downregulated cell survival proteins Bcl-2, 
      Bcl-XL and XIAP in the placenta. CrVI disrupts placental histoarchitecture and 
      increases cell death by spatiotemporal modulation of apoptotic signaling.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Banu, Sakhila K
AU  - Banu SK
AD  - Department of Veterinary Integrative Biosciences, College of Veterinary Medicine 
      and Biomedical Sciences, Mail stop TAMU 4458, Texas A&M University, College 
      Station, TX 77843, USA. Electronic address: skbanu@cvm.tamu.edu.
FAU - Stanley, Jone A
AU  - Stanley JA
AD  - Department of Veterinary Integrative Biosciences, College of Veterinary Medicine 
      and Biomedical Sciences, Mail stop TAMU 4458, Texas A&M University, College 
      Station, TX 77843, USA.
FAU - Sivakumar, Kirthiram K
AU  - Sivakumar KK
AD  - Department of Veterinary Integrative Biosciences, College of Veterinary Medicine 
      and Biomedical Sciences, Mail stop TAMU 4458, Texas A&M University, College 
      Station, TX 77843, USA.
FAU - Arosh, Joe A
AU  - Arosh JA
AD  - Department of Veterinary Integrative Biosciences, College of Veterinary Medicine 
      and Biomedical Sciences, Mail stop TAMU 4458, Texas A&M University, College 
      Station, TX 77843, USA.
FAU - Taylor, Robert J
AU  - Taylor RJ
AD  - Department of Veterinary Integrative Biosciences, College of Veterinary Medicine 
      and Biomedical Sciences, Mail stop TAMU 4458, Texas A&M University, College 
      Station, TX 77843, USA.
FAU - Burghardt, Robert C
AU  - Burghardt RC
AD  - Department of Veterinary Integrative Biosciences, College of Veterinary Medicine 
      and Biomedical Sciences, Mail stop TAMU 4458, Texas A&M University, College 
      Station, TX 77843, USA.
LA  - eng
GR  - P30 ES023512/ES/NIEHS NIH HHS/United States
GR  - R01 ES025234/ES/NIEHS NIH HHS/United States
GR  - R21 ES020561/ES/NIEHS NIH HHS/United States
GR  - S10 RR022532/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160718
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0R0008Q3JB (Chromium)
RN  - 18540-29-9 (chromium hexavalent ion)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Cell Survival/drug effects
MH  - Chromium/*toxicity
MH  - Endocrine Disruptors/*toxicity
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Gestational Age
MH  - Maternal Exposure
MH  - Placenta/*drug effects/metabolism/pathology
MH  - Pregnancy
MH  - Rats, Sprague-Dawley
MH  - Spatio-Temporal Analysis
PMC - PMC5830189
MID - NIHMS944870
OTO - NOTNLM
OT  - Apoptosis
OT  - Hexavalent chromium
OT  - Placenta
OT  - Trophoblasts
COIS- Conflict of interest statement The authors declare that there are no conflicts of 
      interest.
EDAT- 2016/07/23 06:00
MHDA- 2018/01/23 06:00
PMCR- 2018/02/28
CRDT- 2016/07/23 06:00
PHST- 2016/03/28 00:00 [received]
PHST- 2016/07/06 00:00 [revised]
PHST- 2016/07/09 00:00 [accepted]
PHST- 2016/07/23 06:00 [pubmed]
PHST- 2018/01/23 06:00 [medline]
PHST- 2016/07/23 06:00 [entrez]
PHST- 2018/02/28 00:00 [pmc-release]
AID - S0890-6238(16)30263-5 [pii]
AID - 10.1016/j.reprotox.2016.07.006 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2017 Mar;68:171-190. doi: 10.1016/j.reprotox.2016.07.006. Epub 
      2016 Jul 18.