PMID- 27445026
OWN - NLM
STAT- MEDLINE
DCOM- 20170620
LR  - 20180815
IS  - 2241-5955 (Electronic)
IS  - 1109-9666 (Linking)
VI  - 57
IP  - 2
DP  - 2016 Mar-Apr
TI  - Gender differences in the prognostic impact of chronic kidney disease in patients 
      with left ventricular systolic dysfunction following ST elevation myocardial 
      infarction treated with primary percutaneous coronary intervention.
PG  - 109-15
LID - S1109-9666(16)30005-7 [pii]
LID - 10.1016/j.hjc.2015.11.001 [doi]
AB  - BACKGROUND/AIM: Renal function potentially has different prognostic impact in men 
      and women with acute myocardial infarction. The aim of this study was to evaluate 
      the prognostic impact of chronic kidney disease (CKD) on five-year all-cause 
      mortality in men and women with left ventricular systolic dysfunction (LVSD) 
      following ST elevation myocardial infarction (STEMI). METHOD: We included 348 
      consecutive STEMI patients who were treated with primary percutaneous coronary 
      intervention (pPCI) and had a left ventricular ejection fraction < 40%. CKD was 
      defined as baseline creatinine clearance (CrCl) < 60 ml/min. Patients with 
      cardiogenic shock at admission were excluded. RESULTS: Among analyzed patients, 
      104 patients (29.8%) were women, and 244 patients (70.1%) were men. Compared with 
      male patients, female patients were older. Females were more likely to have 
      previous angina and hypertension. CKD was more common in women compared with men 
      (54.8% vs. 22.5%, p<0.001). Female gender and older age were independent 
      predictors of CKD. No significant difference in five-year all-cause mortality was 
      between men and women (27.8% vs. 23.3%, p=0.370). In a Cox regression model 
      (adjustments were made for age, Killip class at admission, post-procedural flow 
      TIMI<3, left main stenosis and women with diabetes), CKD remained an independent 
      predictor of five-year all-cause mortality in men (HR 2.2; 95% CI 1.22-3.3, 
      p=0.007). CONCLUSIONS: Although pre-terminal CKD was more frequently noted in 
      women, it was an independent predictor of five-year mortality exclusively in men. 
      Different prognostic significance of CKD between sexes indicates that renal 
      function must be considered in the prognosis of men and women following acute 
      myocardial infarction.
CI  - Copyright (c) 2016 Hellenic Cardiological Society. Published by Elsevier B.V. All 
      rights reserved.
FAU - Savic, Lidija
AU  - Savic L
AD  - Clinical Centre of Serbia, Emergency Hospital, Coronary Care Unit, Belgrade, 
      Serbia; Clinical Centre of Serbia, Emergency Hospital, Cardiology Clinic, 
      Belgrade, Serbia. Electronic address: lidijasavic@ptt.rs.
FAU - Mrdovic, Igor
AU  - Mrdovic I
AD  - Clinical Centre of Serbia, Emergency Hospital, Coronary Care Unit, Belgrade, 
      Serbia; Clinical Centre of Serbia, Emergency Hospital, Cardiology Clinic, 
      Belgrade, Serbia.
FAU - Asanin, Milika
AU  - Asanin M
AD  - Clinical Centre of Serbia, Emergency Hospital, Coronary Care Unit, Belgrade, 
      Serbia; Clinical Centre of Serbia, Emergency Hospital, Cardiology Clinic, 
      Belgrade, Serbia.
FAU - Stankovic, Sanja
AU  - Stankovic S
AD  - Center for Medical Biochemistry, Emergency Hospital, Clinical Center of Serbia, 
      Belgrade, Serbia.
FAU - Krljanac, Gordana
AU  - Krljanac G
AD  - Clinical Centre of Serbia, Emergency Hospital, Coronary Care Unit, Belgrade, 
      Serbia; Clinical Centre of Serbia, Emergency Hospital, Cardiology Clinic, 
      Belgrade, Serbia.
FAU - Lasica, Ratko
AU  - Lasica R
AD  - Clinical Centre of Serbia, Emergency Hospital, Coronary Care Unit, Belgrade, 
      Serbia.
LA  - eng
PT  - Journal Article
DEP - 20160406
PL  - Netherlands
TA  - Hellenic J Cardiol
JT  - Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese
JID - 101257381
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention
MH  - Prognosis
MH  - Renal Insufficiency, Chronic/complications/*mortality
MH  - ST Elevation Myocardial Infarction/*surgery
MH  - Sex Characteristics
MH  - Survival Rate
MH  - Ventricular Dysfunction, Left/*complications
OTO - NOTNLM
OT  - Chronic kidney disease
OT  - Gender
OT  - ST-elevation myocardial infarction
EDAT- 2016/07/23 06:00
MHDA- 2017/06/21 06:00
CRDT- 2016/07/23 06:00
PHST- 2015/05/14 00:00 [received]
PHST- 2015/12/04 00:00 [accepted]
PHST- 2016/07/23 06:00 [entrez]
PHST- 2016/07/23 06:00 [pubmed]
PHST- 2017/06/21 06:00 [medline]
AID - S1109-9666(16)30005-7 [pii]
AID - 10.1016/j.hjc.2015.11.001 [doi]
PST - ppublish
SO  - Hellenic J Cardiol. 2016 Mar-Apr;57(2):109-15. doi: 10.1016/j.hjc.2015.11.001. 
      Epub 2016 Apr 6.