PMID- 27445464
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160722
LR  - 20220330
IS  - 1177-889X (Print)
IS  - 1177-889X (Electronic)
IS  - 1177-889X (Linking)
VI  - 10
DP  - 2016
TI  - Impact of neuropathy on the adherence to diabetes-related self-care activities: a 
      cross-sectional study.
PG  - 1169-75
LID - 10.2147/PPA.S107621 [doi]
AB  - PURPOSE: The purpose of this study was to evaluate the impact of the presence and 
      severity of neuropathy and depression on the patient's adherence to 
      diabetes-related self-care activities (DRSCA) in a cohort of patients with type 2 
      diabetes mellitus (T2DM). PATIENTS AND METHODS: In this cross-sectional, 
      noninterventional study, 198 patients with T2DM were enrolled according to a 
      population-based, consecutive-case enrollment principle. In all patients, the 
      adherence to DRSCA was evaluated using the Summary of Diabetes Self-Care 
      Activities (SDSCA) questionnaire; a higher SDSCA score is associated with a 
      better adherence. The presence and severity of neuropathy was assessed using the 
      Michigan Neuropathy Screening Instrument (MNSI) and the severity of depression 
      using the Patient Health Questionnaire-9 (PHQ-9). RESULTS: The presence of 
      neuropathy was associated with a decreased SDSCA score (26 points vs 37 points; 
      P<0.001), an increased severe depression prevalence (24.7% vs 4.3%; P<0.001), and 
      an increased PHQ-9 score (12 points vs 7 points; P<0.001). The MNSI score was 
      reverse correlated with SDSCA score (r=-0.527; P<0.001) and positively correlated 
      with PHQ-9 score (r=0.495; P<0.001). The reverse correlation between MNSI score 
      and SDSCA score was present for all the subcomponents of SDSCA questionnaire 
      (diet, exercise, glycemic monitoring, and foot care). CONCLUSION: The presence of 
      neuropathy is associated with decreases in the quality of adherence to DRSCA in 
      patients with T2DM and with increases in the symptomatology of depression. The 
      significant, negative association between the severity of T2DM and the quality of 
      disease self-management points to a possible loop-type relationship between these 
      two components, being possible a reciprocal augmentation with negative 
      consequences on the global management of the disease.
FAU - Timar, Bogdan
AU  - Timar B
AD  - Department of Functional Sciences.
FAU - Timar, Romulus
AU  - Timar R
AD  - Second Department of Internal Medicine.
FAU - Schiller, Adalbert
AU  - Schiller A
AD  - Second Department of Internal Medicine.
FAU - Oancea, Cristian
AU  - Oancea C
AD  - Department of Infectious Diseases.
FAU - Roman, Deiana
AU  - Roman D
AD  - Department of Functional Sciences.
FAU - Vlad, Mihaela
AU  - Vlad M
AD  - Second Department of Internal Medicine.
FAU - Balinisteanu, Bogdan
AU  - Balinisteanu B
AD  - Department of Microscopic Morphology.
FAU - Mazilu, Octavian
AU  - Mazilu O
AD  - First Department of Surgery, "Victor Babes" University of Medicine and Pharmacy, 
      Timisoara, Romania.
LA  - eng
PT  - Journal Article
DEP - 20160701
PL  - New Zealand
TA  - Patient Prefer Adherence
JT  - Patient preference and adherence
JID - 101475748
PMC - PMC4936822
OTO - NOTNLM
OT  - depression
OT  - diabetes self-care
OT  - diabetic neuropathy
OT  - type 2 diabetes mellitus
EDAT- 2016/07/23 06:00
MHDA- 2016/07/23 06:01
PMCR- 2016/07/01
CRDT- 2016/07/23 06:00
PHST- 2016/07/23 06:00 [entrez]
PHST- 2016/07/23 06:00 [pubmed]
PHST- 2016/07/23 06:01 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - ppa-10-1169 [pii]
AID - 10.2147/PPA.S107621 [doi]
PST - epublish
SO  - Patient Prefer Adherence. 2016 Jul 1;10:1169-75. doi: 10.2147/PPA.S107621. 
      eCollection 2016.