PMID- 27446819
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160722
LR  - 20220330
IS  - 2251-6581 (Print)
IS  - 2251-6581 (Electronic)
IS  - 2251-6581 (Linking)
VI  - 15
DP  - 2015
TI  - Dietary insulin load and insulin index are associated with the risk of insulin 
      resistance: a prospective approach in tehran lipid and glucose study.
PG  - 23
LID - 10.1186/s40200-016-0247-5 [doi]
LID - 23
AB  - BACKGROUND: The aim of this study was to investigate the relationship between 
      dietary insulin load (DIL) and insulin index (DII) and the risk of insulin 
      resistance in Tehranian adults. METHODS: In this study, 927 men and women, aged 
      22-80 years, participated in Tehran Lipid and Glucose Study were included. 
      Fasting serum insulin and glucose were measured at baseline and again after a 
      3-year of follow-up. Usual dietary intakes were measured using a validated 168 
      item semi-quantitative food frequency questionnaire and DIL and DII were 
      calculated. Logistic regression models were used to estimate the occurrence of 
      the IR across tertile categories of DIL and DII with adjustment for potential 
      confounding variables. RESULT: Mean age of participants was 40.71 +/- 12.14 y, and 
      mean body mass index (BMI) was 27.23 +/- 4.9 kg/m(2), at baseline. Mean of DIL and 
      DII was 937 +/- 254 and 84.0 +/- 6.3. Participants with higher DIL had higher weight 
      and waist circumference at baseline (P < 0.05). A borderline positive association 
      was observed between DII and the risk of insulin resistance in fully adjusted 
      model (odds ratio = 1.66, 95 % confidence interval = 0.96-2.86, P for 
      trend = 0.06). After adjustment of potential confounders, highest compared to the 
      lowest tertile of DIL was also significantly associated with increased risk of 
      insulin resistance (odds ratio = 1.69, 95 % confidence interval = 1.01-2.89, P 
      for trend = 0.06). CONCLUSION: Dietary insulin load and DII could be considered 
      as independent dietary risk factors for development of insulin resistance.
FAU - Mirmiran, Parvin
AU  - Mirmiran P
AD  - Nutrition and Endocrine Research Center, and Obesity Research Center, Research 
      Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Esfandiari, Saeed
AU  - Esfandiari S
AD  - Nutrition and Endocrine Research Center, and Obesity Research Center, Research 
      Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Bahadoran, Zahra
AU  - Bahadoran Z
AD  - Nutrition and Endocrine Research Center, and Obesity Research Center, Research 
      Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran ; No. 24., Shahid Erabi St., Yeman St., P.O. Box: 19395-4763, 
      Velenjak, Tehran Iran.
FAU - Tohidi, Maryam
AU  - Tohidi M
AD  - Prevention of Metabolic Disorders Research Center, Research Institute for 
      Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Azizi, Fereidoun
AU  - Azizi F
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20160720
PL  - Switzerland
TA  - J Diabetes Metab Disord
JT  - Journal of diabetes and metabolic disorders
JID - 101590741
PMC - PMC4955203
OTO - NOTNLM
OT  - Dietary insulin index
OT  - Dietary insulin load
OT  - Insulin resistance
EDAT- 2015/01/01 00:00
MHDA- 2015/01/01 00:01
PMCR- 2016/07/20
CRDT- 2016/07/23 06:00
PHST- 2016/01/31 00:00 [received]
PHST- 2016/07/13 00:00 [accepted]
PHST- 2016/07/23 06:00 [entrez]
PHST- 2015/01/01 00:00 [pubmed]
PHST- 2015/01/01 00:01 [medline]
PHST- 2016/07/20 00:00 [pmc-release]
AID - 247 [pii]
AID - 10.1186/s40200-016-0247-5 [doi]
PST - epublish
SO  - J Diabetes Metab Disord. 2016 Jul 20;15:23. doi: 10.1186/s40200-016-0247-5. 
      eCollection 2015.