PMID- 27447929
OWN - NLM
STAT- MEDLINE
DCOM- 20170209
LR  - 20191210
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 1031
DP  - 2016 Sep 15
TI  - Simultaneous determination of eight neonicotinoid insecticide residues and two 
      primary metabolites in cucumbers and soil by liquid chromatography-tandem mass 
      spectrometry coupled with QuEChERS.
PG  - 15-28
LID - S1570-0232(16)30396-8 [pii]
LID - 10.1016/j.jchromb.2016.06.020 [doi]
AB  - A new, rapid, sensitive, precise and validated high performance liquid 
      chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) method was 
      developed for the simultaneous determination of eight neonicotinoid insecticides 
      with their two primary metabolites in cucumbers and soil based on QuEChERS as a 
      pretreatment procedure. In QuEChERS procedure, cucumber samples were extracted 
      with acetonitrile and cleaned using (C18 sorbent material), while soil samples 
      were extracted with a mixture of acetonitrile:dichloromethane (8.3:16.7v:v). The 
      LC-MS/MS conditions were optimized to provide good selectivity and specificity of 
      the developed method where neonicotinoids were separated using gradient elution 
      of water and acetonitrile both containing 0.1% formic acid with Gemini C18 column 
      where the last compound was eluted at 9.5min. Average recoveries of the eight 
      neonicotinoids and their metabolites ranged between 81.6% and 95.7% in fortified 
      cucumber samples with relative standard deviations (RSDs) lower than 13.18% and 
      between 80.3% and 104% in fortified soil samples with relative standard 
      deviations (RSDs) lower than 8.44%. The limits of detection (LODs) and 
      quantification (LOQs) for the ten compounds were in the ranges of (0.08-6.06ng/g) 
      and (0.26-20ng/g), respectively. The method was applied successfully to determine 
      residues and rate of disappearance of the eight neonicotinoids from cucumber and 
      soil and their half-lives where a safety pre-harvest interval of 5days for 
      acetampirid, 12days for imidacloprid, 15days for nitenpyram, 12days for 
      thiamethoxam, 5days for flonicamid, 8days for clothianidin, 2days for 
      Dinotefuran, and 1day for thiacloprid were suggested.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Abdel-Ghany, Maha F
AU  - Abdel-Ghany MF
AD  - Pharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Ain Shams 
      University, Cairo, Egypt.
FAU - Hussein, Lobna A
AU  - Hussein LA
AD  - Pharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Ain Shams 
      University, Cairo, Egypt.
FAU - El Azab, Noha F
AU  - El Azab NF
AD  - Pharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Ain Shams 
      University, Cairo, Egypt. Electronic address: noha_3zab@yahoo.com.
FAU - El-Khatib, Ahmed H
AU  - El-Khatib AH
AD  - Pharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Ain Shams 
      University, Cairo, Egypt; Department of Chemistry, Humboldt-Universitat zu 
      Berlin, Berlin, Germany.
FAU - Linscheid, Michael W
AU  - Linscheid MW
AD  - Department of Chemistry, Humboldt-Universitat zu Berlin, Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20160616
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Insecticides)
RN  - LMS11II2LO (Anabasine)
SB  - IM
MH  - Anabasine/*analysis/metabolism
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Cucumis sativus/*metabolism
MH  - Insecticides/*analysis/metabolism
MH  - Limit of Detection
MH  - Reproducibility of Results
MH  - Tandem Mass Spectrometry/*methods
OTO - NOTNLM
OT  - Cucumber
OT  - MS/MS
OT  - Metabolites
OT  - Neonicotinoids
OT  - QuEChERS
OT  - Soil
EDAT- 2016/07/23 06:00
MHDA- 2017/02/10 06:00
CRDT- 2016/07/23 06:00
PHST- 2016/02/24 00:00 [received]
PHST- 2016/06/08 00:00 [revised]
PHST- 2016/06/13 00:00 [accepted]
PHST- 2016/07/23 06:00 [entrez]
PHST- 2016/07/23 06:00 [pubmed]
PHST- 2017/02/10 06:00 [medline]
AID - S1570-0232(16)30396-8 [pii]
AID - 10.1016/j.jchromb.2016.06.020 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Sep 15;1031:15-28. doi: 
      10.1016/j.jchromb.2016.06.020. Epub 2016 Jun 16.