PMID- 27448223
OWN - NLM
STAT- MEDLINE
DCOM- 20170102
LR  - 20220408
IS  - 1435-604X (Electronic)
IS  - 0268-8921 (Linking)
VI  - 31
IP  - 8
DP  - 2016 Nov
TI  - Local adjunct effect of antimicrobial photodynamic therapy for the treatment of 
      chronic periodontitis in type 2 diabetics: split-mouth double-blind randomized 
      controlled clinical trial.
PG  - 1633-1640
AB  - Diabetes has become a global epidemic. Its complications can have a significant 
      impact on quality of life, longevity, and public health costs. The presence of 
      diabetes might impair the prognosis of periodontal treatments due to its negative 
      influence on wound healing. Antimicrobial photodynamic therapy (aPDT) is a local 
      approach that can promote bacterial decontamination in periodontal pockets. The 
      aim of this study was to investigate the local effect of adjunct aPDT to 
      ultrasonic periodontal debridement (UPD) and compare it to UD only for the 
      treatment of chronic periodontitis in type 2 diabetic patients. Twenty type 2 
      diabetic patients with moderate to severe generalized chronic periodontitis were 
      selected. Two periodontal pockets with probing depth (PD) and clinical attachment 
      level (CAL) >/=5 mm received UPD only (UPD group) or UPD plus adjunct aPDT 
      (UPD + aPDT group). Periodontal clinical measures were collected and compared at 
      baseline and 30, 90, and 180 days. After 180 days of follow-up, there were 
      statistically significant reductions in PD from 5.75 +/- 0.91 to 3.47 +/- 0.97 mm in 
      the UPD group and from 6.15 +/- 1.27 to 3.71 +/- 1.63 mm in the UPD + aPDT group. 
      However, intergroup analysis did not reveal statistically significant differences 
      in any of the evaluated clinical parameters (p > 0.05). The adjunct application 
      of aPDT to UPD did not present additional benefits for the treatment of chronic 
      periodontitis in type 2 diabetic patients. The ClinicalTrials.gov identifier of 
      the present study is NCT02627534.
FAU - Castro Dos Santos, Nidia Cristina
AU  - Castro Dos Santos NC
AD  - Department of Diagnosis and Surgery - Division of Periodontics, College of 
      Dentistry - FOSJC, UNESP - Sao Paulo State University, Av. Eng. Francisco Jose 
      Longo, 777, Sao Jose dos Campos, SP, 12245-000, Brazil.
FAU - Andere, Naira Maria Rebelatto Bechara
AU  - Andere NM
AD  - Department of Diagnosis and Surgery - Division of Periodontics, College of 
      Dentistry - FOSJC, UNESP - Sao Paulo State University, Av. Eng. Francisco Jose 
      Longo, 777, Sao Jose dos Campos, SP, 12245-000, Brazil.
FAU - Araujo, Cassia Fernandes
AU  - Araujo CF
AD  - Department of Diagnosis and Surgery - Division of Periodontics, College of 
      Dentistry - FOSJC, UNESP - Sao Paulo State University, Av. Eng. Francisco Jose 
      Longo, 777, Sao Jose dos Campos, SP, 12245-000, Brazil.
FAU - de Marco, Andrea Carvalho
AU  - de Marco AC
AD  - Department of Diagnosis and Surgery - Division of Periodontics, College of 
      Dentistry - FOSJC, UNESP - Sao Paulo State University, Av. Eng. Francisco Jose 
      Longo, 777, Sao Jose dos Campos, SP, 12245-000, Brazil.
FAU - Dos Santos, Lucio Murilo
AU  - Dos Santos LM
AD  - Department of Biosciences and Oral Diagnosis, College of Dentistry - FOSJC, UNESP 
      - Sao Paulo State University, Av. Eng. Francisco Jose Longo, 777, Sao Jose dos 
      Campos, SP, 12245-000, Brazil.
FAU - Jardini, Maria Aparecida Neves
AU  - Jardini MA
AD  - Department of Diagnosis and Surgery - Division of Periodontics, College of 
      Dentistry - FOSJC, UNESP - Sao Paulo State University, Av. Eng. Francisco Jose 
      Longo, 777, Sao Jose dos Campos, SP, 12245-000, Brazil.
FAU - Santamaria, Mauro Pedrine
AU  - Santamaria MP
AD  - Department of Diagnosis and Surgery - Division of Periodontics, College of 
      Dentistry - FOSJC, UNESP - Sao Paulo State University, Av. Eng. Francisco Jose 
      Longo, 777, Sao Jose dos Campos, SP, 12245-000, Brazil. 
      mauro.santamaria@fosjc.unesp.br.
LA  - eng
SI  - ClinicalTrials.gov/NCT02627534
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160722
PL  - England
TA  - Lasers Med Sci
JT  - Lasers in medical science
JID - 8611515
RN  - 0 (Anti-Infective Agents)
SB  - IM
MH  - Anti-Infective Agents/*therapeutic use
MH  - Chronic Disease
MH  - Chronic Periodontitis/complications/*drug therapy
MH  - Combined Modality Therapy
MH  - Diabetes Mellitus, Type 2/complications/*drug therapy
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Photochemotherapy
OTO - NOTNLM
OT  - Antimicrobial therapy
OT  - Chronic periodontitis
OT  - Diabetes mellitus
OT  - Low-level laser therapy
OT  - Periodontal pocket
OT  - Photodynamic therapy
EDAT- 2016/07/23 06:00
MHDA- 2017/01/04 06:00
CRDT- 2016/07/23 06:00
PHST- 2016/03/02 00:00 [received]
PHST- 2016/07/12 00:00 [accepted]
PHST- 2016/07/23 06:00 [pubmed]
PHST- 2017/01/04 06:00 [medline]
PHST- 2016/07/23 06:00 [entrez]
AID - 10.1007/s10103-016-2030-8 [pii]
AID - 10.1007/s10103-016-2030-8 [doi]
PST - ppublish
SO  - Lasers Med Sci. 2016 Nov;31(8):1633-1640. doi: 10.1007/s10103-016-2030-8. Epub 
      2016 Jul 22.