PMID- 27448408
OWN - NLM
STAT- MEDLINE
DCOM- 20171201
LR  - 20211204
IS  - 1756-8722 (Electronic)
IS  - 1756-8722 (Linking)
VI  - 9
IP  - 1
DP  - 2016 Jul 22
TI  - Chasing the precursor of functional hematopoietic stem cells at the single cell 
      levels in mouse embryos.
PG  - 58
LID - 10.1186/s13045-016-0289-7 [doi]
LID - 58
AB  - BACKGROUND: Adult hematopoietic stem cells (HSCs), the ideal system for 
      regenerative research, were isolated at single cell levels decades ago, whereas 
      studies on embryonic HSCs are much more difficult. METHODS: Zhou et al identified 
      a new pre-HSC cell surface marker, CD201, by which they isolated pre-HSCs at 
      single cell levels for further analyses. RESULTS: The novel expression pattern of 
      HSC development is revealed, including the fundamental role of mammalian targets 
      of rapamycin (mTOR) signaling pathway in HSCs emergence, and the repopulation 
      potential of S/G2/M phase pre-HSCs. CONCLUSIONS: Deeper understandings of the 
      cellular origin and developmental regulatory network of HSCs are essential to 
      develop new strategies of generating HSCs in vitro for clinical application.
FAU - Wang, Xiaochen
AU  - Wang X
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Tianjin, 300020, China. xcwang@ihcams.ac.cn.
FAU - Gong, Yuemin
AU  - Gong Y
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Tianjin, 300020, China.
FAU - Ema, Hideo
AU  - Ema H
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Tianjin, 300020, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160722
PL  - England
TA  - J Hematol Oncol
JT  - Journal of hematology & oncology
JID - 101468937
RN  - 0 (Endothelial Protein C Receptor)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Embryonic Stem Cells/*cytology
MH  - Endothelial Protein C Receptor/*analysis
MH  - Hematopoiesis
MH  - Hematopoietic Stem Cells/*cytology
MH  - Human Embryonic Stem Cells
MH  - Humans
MH  - Mice
MH  - Mouse Embryonic Stem Cells
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/physiology
PMC - PMC4957898
OTO - NOTNLM
OT  - Cell-cycle
OT  - HSC
OT  - Pre-HSC
OT  - mTOR
EDAT- 2016/07/28 06:00
MHDA- 2017/12/02 06:00
PMCR- 2016/07/22
CRDT- 2016/07/25 06:00
PHST- 2016/07/08 00:00 [received]
PHST- 2016/07/14 00:00 [accepted]
PHST- 2016/07/25 06:00 [entrez]
PHST- 2016/07/28 06:00 [pubmed]
PHST- 2017/12/02 06:00 [medline]
PHST- 2016/07/22 00:00 [pmc-release]
AID - 10.1186/s13045-016-0289-7 [pii]
AID - 289 [pii]
AID - 10.1186/s13045-016-0289-7 [doi]
PST - epublish
SO  - J Hematol Oncol. 2016 Jul 22;9(1):58. doi: 10.1186/s13045-016-0289-7.