PMID- 27449796
OWN - NLM
STAT- MEDLINE
DCOM- 20180222
LR  - 20191210
IS  - 1364-6753 (Electronic)
IS  - 1364-6745 (Linking)
VI  - 18
IP  - 1
DP  - 2017 Jan
TI  - Circular RNAs-one of the enigmas of the brain.
PG  - 1-6
LID - 10.1007/s10048-016-0490-4 [doi]
AB  - Circular RNAs (circRNAs) provide a new and relatively unexplored class of 
      noncoding RNAs that are predominantly found in mammalian cells. In this review, 
      we present the latest data regarding the structural organization, possible 
      mechanisms of synthesis, and functions of circRNAs. These transcripts were 
      isolated as an RNA fraction that was resistant to RNase R treatment, which 
      selectively destroys the linear forms of RNA molecules. circRNAs are encoded by 
      orthologous genes in different organisms and show tissue- and organ-specific 
      expression. Currently, the biogenesis and functional properties of circRNAs 
      remain unclear; transcripts of this class, however, remain highly promising 
      targets of research. Some of them have been ascribed the function of "molecular 
      sponges" that can absorb microRNAs, RNA-binding proteins, and small nuclear RNAs. 
      circRNAs are often formed from the RNA portions of protein-coding genes in the 
      course of alternative splicing. Some features of the circRNAs of mammals were 
      demonstrated using 11 circRNAs of the human sphingomyelin synthase 1 gene 
      (SGMS1), which were discovered by us in the brain. These circRNAs consist mainly 
      of portions of the multi-exon 5' untranslated region (5'UTR) of the SGMS1 gene 
      and include one to five exons. The synthesis of circRNAs may be new, previously 
      unknown, function of the multi-exon 5'UTR of genes. This feature is most clearly 
      manifested in the brain, where the level of circRNAs is significantly higher.
FAU - Filippenkov, Ivan B
AU  - Filippenkov IB
AD  - Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, 
      Russia. Filippenkov@img.ras.ru.
FAU - Kalinichenko, Eugene O
AU  - Kalinichenko EO
AD  - Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, 
      Russia.
FAU - Limborska, Svetlana A
AU  - Limborska SA
AD  - Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, 
      Russia.
AD  - Pirogov Russian National Research Medical University, Moscow, 117997, Russia.
FAU - Dergunova, Lyudmila V
AU  - Dergunova LV
AD  - Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, 
      Russia.
AD  - Pirogov Russian National Research Medical University, Moscow, 117997, Russia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160723
PL  - United States
TA  - Neurogenetics
JT  - Neurogenetics
JID - 9709714
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Circular)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Genetic Variation
MH  - Humans
MH  - Mammals/genetics
MH  - MicroRNAs/physiology
MH  - RNA/*physiology
MH  - RNA, Circular
OTO - NOTNLM
OT  - Circular RNAs
OT  - Inverted repeats
OT  - Multi-exon 5'UTR
OT  - Sphingomyelin synthase 1 gene
OT  - Tissue-specific expression
OT  - microRNA
EDAT- 2016/07/28 06:00
MHDA- 2018/02/23 06:00
CRDT- 2016/07/25 06:00
PHST- 2016/04/26 00:00 [received]
PHST- 2016/07/11 00:00 [accepted]
PHST- 2016/07/28 06:00 [pubmed]
PHST- 2018/02/23 06:00 [medline]
PHST- 2016/07/25 06:00 [entrez]
AID - 10.1007/s10048-016-0490-4 [pii]
AID - 10.1007/s10048-016-0490-4 [doi]
PST - ppublish
SO  - Neurogenetics. 2017 Jan;18(1):1-6. doi: 10.1007/s10048-016-0490-4. Epub 2016 Jul 
      23.