PMID- 27450876
OWN - NLM
STAT- MEDLINE
DCOM- 20171023
LR  - 20180314
IS  - 1876-7591 (Electronic)
IS  - 1876-7591 (Linking)
VI  - 9
IP  - 12
DP  - 2016 Dec
TI  - Prognostic Value of LGE-CMR in HCM: A Meta-Analysis.
PG  - 1392-1402
LID - S1936-878X(16)30406-5 [pii]
LID - 10.1016/j.jcmg.2016.02.031 [doi]
AB  - OBJECTIVES: The aims of this study included performing a meta-analysis of the 
      predictive value of late gadolinium enhancement (LGE) cardiac magnetic resonance 
      (CMR) for adverse events and death in hypertrophic cardiomyopathy (HCM). 
      BACKGROUND: CMR with LGE can identify areas of myocardial fibrosis; however, 
      controversies remain regarding the independent prognostic importance of LGE-CMR 
      in HCM. METHODS: We searched PubMed and Web of Science for studies that 
      investigated the prognostic value of LGE in patients with HCM. Pooled odds ratios 
      (ORs), hazard ratios (HRs), and 95% confidence intervals (CIs) were calculated to 
      assess the role of LGE CMR in the risk stratification of HCM. RESULTS: Seven 
      studies were retrieved from 393 citations for the analysis, of which 2 were 
      eliminated because of overlapping data. In total, 2,993 patients (mean age 54.6 
      years; median follow-up 36.8 months) were included in the analysis. Meta-analysis 
      showed the presence of LGE was associated with an increased risk for sudden 
      cardiac death (SCD) (OR: 3.41; 95% CI:1.97 to 5.94; p < 0.001), all-cause 
      mortality (OR: 1.80, 95% CI: 1.21 to 2.69; p = 0.004), cardiovascular mortality 
      (OR: 2.93, 95% CI: 1.53 to 5.61; p = 0.001), and a trend for heart failure 
      death (OR: 2.21, 95% CI: 0.84 to 5.80; p = 0.107). Extent of LGE was associated 
      with an increased risk of SCD (HR: 1.56/10% LGE; 95% CI: 1.33 to 1.82; p < 
      0.0001), heart failure death (HR: 1.61/10% LGE; 95% CI: 1.21 to 2.13; p = 0.001), 
      all-cause mortality (HR: 1.29/10% LGE; 95% CI: 1.09 to 1.51; p = 0.002), and 
      cardiovascular mortality (HR: 1.57/10% LGE; 95% CI: 1.30 to 1.89; p < 0.001). 
      After adjusting for baseline characteristics, the extent of LGE remained strongly 
      associated with the risk of SCD (HR(adjusted): 1.36/10% LGE; 95% CI: 1.10 to 
      1.69; p = 0.005). CONCLUSIONS: Quantitative LGE by CMR exhibited a substantial 
      prognostic value in SCD events prediction, independent of baseline 
      characteristics. Assessment of LGE can be used as an effective tool for risk 
      stratifying patients with HCM.
CI  - Copyright A(c) 2016 American College of Cardiology Foundation. Published by 
      Elsevier Inc. All rights reserved.
FAU - Weng, Zhen
AU  - Weng Z
AD  - Cyrus Tang Hematology Center and Ministry of Education Engineering Center of 
      Hematological Disease, the First Affiliated Hospital, and the Collaborative 
      Innovation Center of Hematology, Soochow University, Suzhou, China.
FAU - Yao, Jialu
AU  - Yao J
AD  - Department of Cardiology, the First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Chan, Raymond H
AU  - Chan RH
AD  - Division of Cardiology, Peter Munk Cardiac Center, Toronto General Hospital, 
      University Health Network, University of Toronto, Toronto, Ontario, Canada.
FAU - He, Jun
AU  - He J
AD  - Cyrus Tang Hematology Center and Ministry of Education Engineering Center of 
      Hematological Disease, the First Affiliated Hospital, and the Collaborative 
      Innovation Center of Hematology, Soochow University, Suzhou, China.
FAU - Yang, Xiangjun
AU  - Yang X
AD  - Department of Cardiology, the First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Zhou, Yafeng
AU  - Zhou Y
AD  - Department of Cardiology, the First Affiliated Hospital of Soochow University, 
      Suzhou, China. Electronic address: zhouyafeng@medmail.com.cn.
FAU - He, Yang
AU  - He Y
AD  - Cyrus Tang Hematology Center and Ministry of Education Engineering Center of 
      Hematological Disease, the First Affiliated Hospital, and the Collaborative 
      Innovation Center of Hematology, Soochow University, Suzhou, China. Electronic 
      address: heyang1963@163.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160720
PL  - United States
TA  - JACC Cardiovasc Imaging
JT  - JACC. Cardiovascular imaging
JID - 101467978
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - JACC Cardiovasc Imaging. 2016 Dec;9(12 ):1403-1406. PMID: 27450875
MH  - Cardiomyopathy, Hypertrophic/complications/*diagnostic imaging/mortality
MH  - Contrast Media/*administration & dosage
MH  - Death, Sudden, Cardiac/etiology
MH  - Female
MH  - Gadolinium/*administration & dosage
MH  - Heart Failure/etiology/mortality
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Risk Factors
MH  - Time Factors
OTO - NOTNLM
OT  - cardiac magnetic resonance
OT  - hypertrophic cardiomyopathy
OT  - late gadolinium enhancement
OT  - meta-analysis
OT  - myocardial fibrosis
EDAT- 2016/07/28 06:00
MHDA- 2017/10/24 06:00
CRDT- 2016/07/25 06:00
PHST- 2015/10/08 00:00 [received]
PHST- 2016/02/22 00:00 [revised]
PHST- 2016/02/25 00:00 [accepted]
PHST- 2016/07/28 06:00 [pubmed]
PHST- 2017/10/24 06:00 [medline]
PHST- 2016/07/25 06:00 [entrez]
AID - S1936-878X(16)30406-5 [pii]
AID - 10.1016/j.jcmg.2016.02.031 [doi]
PST - ppublish
SO  - JACC Cardiovasc Imaging. 2016 Dec;9(12):1392-1402. doi: 
      10.1016/j.jcmg.2016.02.031. Epub 2016 Jul 20.