PMID- 27452805
OWN - NLM
STAT- MEDLINE
DCOM- 20171124
LR  - 20191210
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 315
DP  - 2016 Dec 15
TI  - Long-term caloric restriction in mice may prevent age-related learning impairment 
      via suppression of apoptosis.
PG  - 45-50
LID - S0166-4328(16)30464-8 [pii]
LID - 10.1016/j.bbr.2016.07.036 [doi]
AB  - Caloric restriction (CR) is the most reliable intervention to extend lifespan and 
      prevent age-related disorders in various species from yeast to rodents. However, 
      the underlying mechanisms have not yet been clearly defined. Therefore, we aimed 
      to identify the underlying mechanisms of long-term CR on age-related learning 
      impairment in C57/BL mice. Thirty six-week-old male C57/BL mice were randomly 
      divided into three groups: normal control group (NC group, n=10), high energy 
      group (HE group, n=10), and CR group (n=10). After 10 months, the Morris water 
      maze test was performed to monitor learning abilities. Western blotting, 
      immunohistochemistry and real-time polymerase chain reaction were used to monitor 
      changes in protein and mRNA levels associated with apoptosis-related proteins in 
      the hippocampus. The average escape latency was lower in the CR group compared 
      with the NC group, and the average time taken to first cross the platform in the 
      CR group was significantly shorter than the HE group. Both Bcl-2 protein and mRNA 
      expression levels in the CR group were significantly higher than those of the NC 
      group and HE group. The expression of Bax, Caspase-3 and PARP protein in the CR 
      group was significantly lower than the NC group. Our findings demonstrate that 
      long-term CR may prevent age-related learning impairments via suppressing 
      apoptosis in mice.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Ma, Lina
AU  - Ma L
AD  - Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing 
      100053, China; Central Laboratory, Xuan Wu Hospital, Capital Medical University, 
      Key Laboratory for Neurodegenerative Disease of Ministry of Education, Center of 
      Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing 100053, 
      China.
FAU - Wang, Rong
AU  - Wang R
AD  - Central Laboratory, Xuan Wu Hospital, Capital Medical University, Key Laboratory 
      for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer's 
      Disease, Beijing Institute for Brain Disorders, Beijing 100053, China. Electronic 
      address: rong_wang72@aliyun.com.
FAU - Dong, Wen
AU  - Dong W
AD  - Central Laboratory, Xuan Wu Hospital, Capital Medical University, Key Laboratory 
      for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer's 
      Disease, Beijing Institute for Brain Disorders, Beijing 100053, China.
FAU - Li, Yun
AU  - Li Y
AD  - Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing 
      100053, China.
FAU - Xu, Baolei
AU  - Xu B
AD  - Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing 
      100053, China.
FAU - Zhang, Jingshuang
AU  - Zhang J
AD  - Central Laboratory, Xuan Wu Hospital, Capital Medical University, Key Laboratory 
      for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer's 
      Disease, Beijing Institute for Brain Disorders, Beijing 100053, China.
FAU - Zhao, Zhiwei
AU  - Zhao Z
AD  - Central Laboratory, Xuan Wu Hospital, Capital Medical University, Key Laboratory 
      for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer's 
      Disease, Beijing Institute for Brain Disorders, Beijing 100053, China.
LA  - eng
PT  - Journal Article
DEP - 20160721
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (RNA, Messenger)
RN  - 0 (bcl-2-Associated X Protein)
RN  - EC 2.4.2.30 (Poly(ADP-ribose) Polymerases)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Apoptosis/*physiology
MH  - *Caloric Restriction/methods
MH  - Caspase 3/metabolism
MH  - Learning Disabilities/*prevention & control
MH  - Male
MH  - Maze Learning
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Poly(ADP-ribose) Polymerases/metabolism
MH  - Proto-Oncogene Proteins c-bcl-2/metabolism
MH  - RNA, Messenger
MH  - Random Allocation
MH  - bcl-2-Associated X Protein/metabolism
OTO - NOTNLM
OT  - Ageing
OT  - Apoptosis
OT  - Caloric restriction
OT  - Learning ability
EDAT- 2016/07/28 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/07/26 06:00
PHST- 2016/04/10 00:00 [received]
PHST- 2016/07/15 00:00 [revised]
PHST- 2016/07/20 00:00 [accepted]
PHST- 2016/07/26 06:00 [entrez]
PHST- 2016/07/28 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - S0166-4328(16)30464-8 [pii]
AID - 10.1016/j.bbr.2016.07.036 [doi]
PST - ppublish
SO  - Behav Brain Res. 2016 Dec 15;315:45-50. doi: 10.1016/j.bbr.2016.07.036. Epub 2016 
      Jul 21.