PMID- 27453537
OWN - NLM
STAT- MEDLINE
DCOM- 20170922
LR  - 20211217
IS  - 1751-7176 (Electronic)
IS  - 1524-6175 (Print)
IS  - 1524-6175 (Linking)
VI  - 19
IP  - 1
DP  - 2017 Jan
TI  - Monocyte Chemoattractant Protein-1 and Large Artery Structure and Function in 
      Young Individuals: The African-PREDICT Study.
PG  - 67-74
LID - 10.1111/jch.12868 [doi]
AB  - To better understand hypertension development, the authors determined whether 
      monocyte chemoattractant protein-1 (MCP-1) is associated with arterial stiffness 
      (pulse wave velocity [PWV]) and carotid intima-media wall thickness (cIMT) in a 
      young apparently healthy black and white population (N=403, aged 20-30 years). 
      Carotid-femoral PWV, central systolic blood pressure, and cIMT were measured, and 
      MCP-1, reactive oxygen species, inflammatory markers (interleukin 6, tumor 
      necrosis factor alpha), and endothelial activation (intercellular adhesion molecule, 
      vascular cell adhesion molecule) were determined from blood samples. Although 
      carotid-femoral PWV and cIMT were similar between blacks and whites, black men 
      and women showed higher central systolic blood pressure, MCP-1, and reactive 
      oxygen species than whites (all P<.05). In addition, black women had higher 
      brachial blood pressure and interleukin 6 (all P<.001). A consistent positive 
      association only in black women between cIMT and MCP-1 in multiple regression 
      analyses was found (R(2)=0.151, beta=0.248; P=.021). In this model, cIMT was also 
      independently associated with vascular cell adhesion molecule (beta=0.251; P=.022). 
      The authors found elevated central systolic blood pressure and MCP-1 in young 
      blacks, where cIMT was independently associated with MCP-1 in black women.
CI  - (c)2016 Wiley Periodicals, Inc.
FAU - Kriel, Johanna I
AU  - Kriel JI
AD  - Hypertension in Africa Research Team, North-West University, Potchefstroom, South 
      Africa.
FAU - Fourie, Carla M T
AU  - Fourie CM
AD  - Hypertension in Africa Research Team, North-West University, Potchefstroom, South 
      Africa.
FAU - Schutte, Aletta E
AU  - Schutte AE
AD  - Hypertension in Africa Research Team, North-West University, Potchefstroom, South 
      Africa.
AD  - MRC Research Unit on Hypertension and Cardiovascular Disease, North-West 
      University, Potchefstroom, South Africa.
LA  - eng
GR  - MC_PC_16095/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160725
PL  - United States
TA  - J Clin Hypertens (Greenwich)
JT  - Journal of clinical hypertension (Greenwich, Conn.)
JID - 100888554
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Blood Pressure
MH  - Carotid Arteries/metabolism/*physiopathology
MH  - Carotid Intima-Media Thickness
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Hypertension/ethnology/*metabolism/physiopathology
MH  - Male
MH  - Pulse Wave Analysis
MH  - South Africa/ethnology
MH  - Vascular Stiffness
MH  - Young Adult
PMC - PMC8030831
EDAT- 2016/07/28 06:00
MHDA- 2017/09/25 06:00
PMCR- 2016/07/25
CRDT- 2016/07/26 06:00
PHST- 2016/03/09 00:00 [received]
PHST- 2016/05/05 00:00 [revised]
PHST- 2016/05/20 00:00 [accepted]
PHST- 2016/07/28 06:00 [pubmed]
PHST- 2017/09/25 06:00 [medline]
PHST- 2016/07/26 06:00 [entrez]
PHST- 2016/07/25 00:00 [pmc-release]
AID - JCH12868 [pii]
AID - 10.1111/jch.12868 [doi]
PST - ppublish
SO  - J Clin Hypertens (Greenwich). 2017 Jan;19(1):67-74. doi: 10.1111/jch.12868. Epub 
      2016 Jul 25.