PMID- 27454660
OWN - NLM
STAT- MEDLINE
DCOM- 20170623
LR  - 20220321
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 57
IP  - 9
DP  - 2016 Jul 1
TI  - Structural Change Can Be Detected in Advanced-Glaucoma Eyes.
PG  - OCT511-8
LID - 10.1167/iovs.15-18929 [doi]
AB  - PURPOSE: To compare spectral-domain optical coherence tomography (SD-OCT) 
      standard structural measures and a new three-dimensional (3D) volume optic nerve 
      head (ONH) change detection method for detecting change over time in severely 
      advanced-glaucoma (open-angle glaucoma [OAG]) patients. METHODS: Thirty-five eyes 
      of 35 patients with very advanced glaucoma (defined as a visual field mean 
      deviation < -21 dB) and 46 eyes of 30 healthy subjects to estimate aging changes 
      were included. Circumpapillary retinal fiber layer thickness (cpRNFL), minimum 
      rim width (MRW), and macular retinal ganglion cell-inner plexiform layer (GCIPL) 
      thicknesses were measured using the San Diego Automated Layer Segmentation 
      Algorithm (SALSA). Progression was defined as structural loss faster than 95th 
      percentile of healthy eyes. Three-dimensional volume ONH change was estimated 
      using the Bayesian-kernel detection scheme (BKDS), which does not require 
      extensive retinal layer segmentation. RESULTS: The number of progressing glaucoma 
      eyes identified was highest for 3D volume BKDS (13, 37%), followed by GCPIL (11, 
      31%), cpRNFL (4, 11%), and MRW (2, 6%). In advanced-OAG eyes, only the mean rate 
      of GCIPL change reached statistical significance, -0.18 mum/y (P = 0.02); the mean 
      rates of cpRNFL and MRW change were not statistically different from zero. In 
      healthy eyes, the mean rates of cpRNFL, MRW, and GCIPL change were significantly 
      different from zero. (all P < 0.001). CONCLUSIONS: Ganglion cell-inner plexiform 
      layer and 3D volume BKDS show promise for identifying change in severely advanced 
      glaucoma. These results suggest that structural change can be detected in very 
      advanced disease. Longer follow-up is needed to determine whether changes 
      identified are false positives or true progression.
FAU - Belghith, Akram
AU  - Belghith A
AD  - Shiley Eye Institute Hamilton Glaucoma Center, University of California, San 
      Diego, La Jolla, California, United States.
FAU - Medeiros, Felipe A
AU  - Medeiros FA
AD  - Shiley Eye Institute Hamilton Glaucoma Center, University of California, San 
      Diego, La Jolla, California, United States.
FAU - Bowd, Christopher
AU  - Bowd C
AD  - Shiley Eye Institute Hamilton Glaucoma Center, University of California, San 
      Diego, La Jolla, California, United States.
FAU - Liebmann, Jeffrey M
AU  - Liebmann JM
AD  - Harkness Eye Institute, Columbia University, New York, New York, United States.
FAU - Girkin, Christopher A
AU  - Girkin CA
AD  - Ophthalmology, University of Alabama, Birmingham, Alabama, United States.
FAU - Weinreb, Robert N
AU  - Weinreb RN
AD  - Shiley Eye Institute Hamilton Glaucoma Center, University of California, San 
      Diego, La Jolla, California, United States.
FAU - Zangwill, Linda M
AU  - Zangwill LM
AD  - Shiley Eye Institute Hamilton Glaucoma Center, University of California, San 
      Diego, La Jolla, California, United States.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - *Algorithms
MH  - Bayes Theorem
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Female
MH  - Glaucoma, Open-Angle/*diagnosis/physiopathology
MH  - Humans
MH  - Imaging, Three-Dimensional/*methods
MH  - Intraocular Pressure/*physiology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Optic Disk/*pathology
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Retinal Ganglion Cells/*pathology
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Field Tests
MH  - Visual Fields
PMC - PMC4968923
EDAT- 2016/07/28 06:00
MHDA- 2017/06/24 06:00
PMCR- 2017/01/01
CRDT- 2016/07/26 06:00
PHST- 2016/07/26 06:00 [entrez]
PHST- 2016/07/28 06:00 [pubmed]
PHST- 2017/06/24 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 2538823 [pii]
AID - IOVS-15-18929 [pii]
AID - 10.1167/iovs.15-18929 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT511-8. doi: 10.1167/iovs.15-18929.