PMID- 27455006
OWN - NLM
STAT- MEDLINE
DCOM- 20160922
LR  - 20160726
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 33
IP  - 4
DP  - 2016 Aug
TI  - [Study of two cases of prenatally detected small supernumerary marker 
      chromosomes].
PG  - 498-500
LID - 10.3760/cma.j.issn.1003-9406.2016.04.015 [doi]
AB  - OBJECTIVE: To determine the origin of two prenatally detected small supernumerary 
      marker chromosomes (sSMCs). METHODS: The sSMCs were analyzed with combined 
      G-banding, C-banding, fluorescence in situ hybridization (FISH), and single 
      nucleotide polymorphisms array (SNP-array) techniques. RESULTS: In case 1, 
      G-banding analysis has identified a 47,XY,+mar karyotype. Affymetrix CytoScan 
      750K Array scan has suggested arr 15q11.2q12(22 770 421-26 604 587)?, while FISH 
      analysis suggested 47,XN,+mar.ish i(15)(q12)(D15Z1+,SNRPN++,PML-). In case 2, 
      G-banding analysis has suggested 46,X,+mar/46,XY, FISH analysis showed two SRY 
      hybridization signals, indicating 46,X,i(Y)(p10)/46,XY. CONCLUSION: Multiple 
      techniques needed be applied for verification of the origin of sSMCs identified 
      in prenatal diagnosis.
FAU - Zeng, Yan
AU  - Zeng Y
AD  - Genetics Laboratory, Shaoxing Women and Children's Hospital, Shaoxing, Zhejiang 
      312000, China. Email: 2560336019@qq.com.
FAU - Fan, Jiaming
AU  - Fan J
FAU - Xu, Ping
AU  - Xu P
FAU - Zhang, Lifang
AU  - Zhang L
FAU - Qian, Feiyan
AU  - Qian F
FAU - Luo, Tingting
AU  - Luo T
LA  - chi
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - Female
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Multiplex Polymerase Chain Reaction
MH  - Oligonucleotide Array Sequence Analysis
MH  - Polymorphism, Single Nucleotide
MH  - *Prenatal Diagnosis
EDAT- 2016/07/28 06:00
MHDA- 2016/09/23 06:00
CRDT- 2016/07/26 06:00
PHST- 2016/07/26 06:00 [entrez]
PHST- 2016/07/28 06:00 [pubmed]
PHST- 2016/09/23 06:00 [medline]
AID - 940632101 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2016.04.015 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016 Aug;33(4):498-500. doi: 
      10.3760/cma.j.issn.1003-9406.2016.04.015.