PMID- 27456089
OWN - NLM
STAT- MEDLINE
DCOM- 20170509
LR  - 20170509
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 19
IP  - 10
DP  - 2016 Oct
TI  - Arthritis in childhood human immunodeficiency virus infection predominantly 
      associated with human leukocyte antigen B27.
PG  - 1018-1023
LID - 10.1111/1756-185X.12947 [doi]
AB  - AIM: Children with human immunodeficiency virus (HIV) infection usually present 
      with recurrent and unusual infections. Although reported among adults, arthritis 
      as a predominant presentation in children with HIV is rare. Reactive arthritis is 
      considered to be the most common musculoskeletal manifestation in adults with HIV 
      infection. However, in children, septic or HIV-related arthritis has been 
      described. We report four children having arthritis with HIV disease and their 
      long-term outcome; out of which three had human leukocyte antigen 
      (HLA)-B27-related arthritis. It is important to be aware of arthritic 
      presentation of HIV disease in children to prevent delay in diagnosis and 
      initiation of appropriate therapy. METHODS: Clinical profile of children with HIV 
      infection who presented with arthritis and registered at the Pediatric 
      Immunodeficiency Clinic at PGIMER, Chandigarh were reviewed and analyzed. 
      RESULTS: A total of 796 children with HIV infection are registered in the 
      Pediatric Immunodeficiency Clinic since January 1994. Among these, four children 
      had arthritis, and it was the presenting manifestation in two of them. HLA-B27 
      related arthritis was noted in three children, while one had HIV-associated 
      arthritis. None of the children had septic arthritis. Arthritis resolved on 
      treatment with antiretroviral therapy (ART) in two children, while others 
      responded to anti-inflammatory agents and the joint symptoms remained quiescent 
      on follow-up with a total follow-up period of 21.5 patient years. CONCLUSIONS: 
      Clinicians must be aware of the arthritic presentation of childhood HIV 
      infection. High degree of suspicion must be entertained to screen for HIV 
      infection in children with arthritis, especially in those with reactive 
      arthritis.
CI  - (c) 2016 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons 
      Australia, Ltd.
FAU - Suri, Deepti
AU  - Suri D
AD  - Allergy-Immunology Unit, Department of Pediatrics, Postgraduate Institute of 
      Medical Education and Research (PGIMER), Chandigarh, India. surideepti@gmail.com.
FAU - Sharma, Avinash
AU  - Sharma A
AUID- ORCID: 0000-0003-4433-4355
AD  - Allergy-Immunology Unit, Department of Pediatrics, Postgraduate Institute of 
      Medical Education and Research (PGIMER), Chandigarh, India.
FAU - Bhattad, Sagar
AU  - Bhattad S
AD  - Allergy-Immunology Unit, Department of Pediatrics, Postgraduate Institute of 
      Medical Education and Research (PGIMER), Chandigarh, India.
FAU - Rawat, Amit
AU  - Rawat A
AD  - Allergy-Immunology Unit, Department of Pediatrics, Postgraduate Institute of 
      Medical Education and Research (PGIMER), Chandigarh, India.
FAU - Arora, Sunil
AU  - Arora S
AD  - Department of Immuno-Pathology, Postgraduate Institute of Medical Education and 
      Research (PGIMER), Chandigarh, India.
FAU - Minz, Ranjana W
AU  - Minz RW
AD  - Department of Immuno-Pathology, Postgraduate Institute of Medical Education and 
      Research (PGIMER), Chandigarh, India.
FAU - Singh, Surjit
AU  - Singh S
AD  - Allergy-Immunology Unit, Department of Pediatrics, Postgraduate Institute of 
      Medical Education and Research (PGIMER), Chandigarh, India.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160726
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Age Factors
MH  - Age of Onset
MH  - Anti-HIV Agents/therapeutic use
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Arthritis, Reactive/diagnosis/drug therapy/*immunology
MH  - Child
MH  - Child, Preschool
MH  - HIV Infections/diagnosis/drug therapy/*immunology/virology
MH  - HLA-B27 Antigen/*immunology
MH  - Humans
MH  - India
MH  - Male
MH  - Registries
MH  - Remission Induction
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - ART
OT  - HLA-B27
OT  - reactive arthritis
OT  - rheumatological
EDAT- 2016/10/30 06:00
MHDA- 2017/05/10 06:00
CRDT- 2016/07/27 06:00
PHST- 2016/10/30 06:00 [pubmed]
PHST- 2017/05/10 06:00 [medline]
PHST- 2016/07/27 06:00 [entrez]
AID - 10.1111/1756-185X.12947 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2016 Oct;19(10):1018-1023. doi: 10.1111/1756-185X.12947. Epub 
      2016 Jul 26.