PMID- 27456877
OWN - NLM
STAT- MEDLINE
DCOM- 20170227
LR  - 20170227
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 8
DP  - 2016 Jul
TI  - Interleukin 7 receptor polymorphisms and the risk of multiple sclerosis: A 
      meta-analysis.
PG  - 66-73
LID - S2211-0348(16)30055-4 [pii]
LID - 10.1016/j.msard.2016.05.001 [doi]
AB  - BACKGROUND: Multiple sclerosis (MS) is considered as the most common chronic 
      inflammatory neurologic disorder diagnosed in young adults. Both environmental 
      and genetic factors may influence risk of MS development. Interleukin 7 receptor 
      (IL7R) is one of the most studied gene polymorphism on MS that may play a 
      possible role in MS development. The most studied polymorphism of IL7R gene is 
      "rs6897932" polymorphism on IL7Ralpha gene (IL7RA). METHODS: PubMed, Scopus, and 
      Google scholar databases were searched for all of related studies on the 
      association of IL7RA polymorphism with single nucleotide polymorphism (SNP) ID of 
      "rs6897932" and the risk of MS through August 07, 2015. After exclusion of 
      irrelevant articles, 11 eligible studies were selected, which were analyzed to 
      determine an association between the MS and IL7R T244I polymorphism (rs6897932). 
      For identification of this association, odds ratios (ORs) and 95% confidence 
      interval (95% CI) were calculated. Four models of allelic (T vs. C), co-dominant 
      genotype (TT vs. CC), dominant (TT+CT vs. CC), and recessive genotypes (TT vs. 
      CT+CC) were considered to check the possible role of rs6897932 polymorphism in 
      MS. A sensitivity analysis was conducted to find the reliability of this study. 
      Furthermore, funnel plots were used to evaluate publication bias. RESULTS: A 
      total of 11 case-control studies were identified through this meta-analysis, 
      which containing 6752 cases and 7349 controls. In overall, the frequency of the C 
      allele was found to be higher in patients with MS compared to healthy controls 
      (75.66% vs. 72.19%). T allele was significantly associated with the decreased 
      risk of MS in a random effect model (T vs. C: OR=0.84, 95% CI=0.77-0.92, P-value 
      <0.001). In the co-dominant, dominant, and recessive genotypes models, a 
      significant association between the IL7R T244I polymorphism and MS risk was 
      demonstrated (TT vs. CC: OR=0.70, 95% CI=0.61-0.80, P-value <0.001; TT+CT vs. CC: 
      OR=0.82, 95% CI=0.73-0.92, P-value <0.001; TT vs. CT+CC: OR=0.76, 95% 
      CI=0.66-0.87, P-value <0.001). Sensitivity analysis revealed that this study is 
      reliable. There was no evidence of publication bias. CONCLUSION: It was 
      demonstrated that the IL7R T244I polymorphism was associated with susceptibility 
      to MS. However, more well-designed studies with large sample size are needed to 
      validate this association between this single nucleotide polymorphism and MS.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Tavakolpour, Soheil
AU  - Tavakolpour S
AD  - Iran University of Medical Sciences, Tehran, Iran; Neuroscience Research center, 
      Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran; Department of Neurology, Tehran University of Medical Sciences, Tehran, 
      Iran. Electronic address: soheil.tavakolpour@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20160502
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
RN  - 0 (Receptors, Interleukin-7)
SB  - IM
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Multiple Sclerosis/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Interleukin-7/*genetics
OTO - NOTNLM
OT  - Interleukin 7 receptor
OT  - Meta-analysis
OT  - Multiple sclerosis
OT  - Polymorphisms
OT  - Rs6897932
EDAT- 2016/07/28 06:00
MHDA- 2017/02/28 06:00
CRDT- 2016/07/27 06:00
PHST- 2015/08/19 00:00 [received]
PHST- 2016/04/17 00:00 [revised]
PHST- 2016/05/01 00:00 [accepted]
PHST- 2016/07/27 06:00 [entrez]
PHST- 2016/07/28 06:00 [pubmed]
PHST- 2017/02/28 06:00 [medline]
AID - S2211-0348(16)30055-4 [pii]
AID - 10.1016/j.msard.2016.05.001 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2016 Jul;8:66-73. doi: 10.1016/j.msard.2016.05.001. Epub 
      2016 May 2.