PMID- 27457498
OWN - NLM
STAT- MEDLINE
DCOM- 20170131
LR  - 20221207
IS  - 1600-0463 (Electronic)
IS  - 0903-4641 (Linking)
VI  - 124
IP  - 10
DP  - 2016 Oct
TI  - Association of human leukocyte antigen with postherpetic neuralgia in Koreans.
PG  - 865-71
LID - 10.1111/apm.12575 [doi]
AB  - Postherpetic neuralgia (PHN), the most frequent complication of varicella-zoster 
      virus reactivation, is characterized by pain that persists for more than 3 
      months, often for years after healing of zoster rash. A few studies revealing the 
      association of human leukocyte antigen (HLA) with PHN have been reported, but 
      only in the Japanese. The aim of this study was to investigate the primary HLA 
      locus associated with PHN susceptibility in Koreans. We compared HLA-A, -B, -C, 
      and DRB1 genotypes of 66 PHN patients with those of 54 herpes zoster (HZ) 
      patients without developing PHN and 235 healthy controls. Frequencies of 
      HLA-B*13, B*44, B*15 (B75), DRB1*10:01, and DRB1*12:02 were increased, and those 
      of HLA-C*01, C*12, and DRB1*01:01 were decreased in PHN patients compared to 
      those in controls (each, p < 0.05). Among these alleles, only the frequency of 
      HLA-B*44 was significantly increased in PHN patients compared to that in HZ 
      patients and the change was due to HLA-B*44:03 (PHN vs controls, p = 0.043; PHN 
      vs HZ, p = 0.012). The results suggest that HLA-B*44:03 or other closely linked 
      gene of the major histocompatibility complex is associated with susceptibility to 
      the development of PHN after HZ, but not with the onset of HZ.
CI  - (c) 2016 APMIS. Published by John Wiley & Sons Ltd.
FAU - Chung, Hye Yoon
AU  - Chung HY
AD  - Department of Laboratory Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Song, Eun Young
AU  - Song EY
AD  - Department of Laboratory Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Yoon, Jung Ah
AU  - Yoon JA
AD  - Department of Laboratory Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Suh, Dae Hun
AU  - Suh DH
AD  - Department of Dermatology, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Lee, Sang Chul
AU  - Lee SC
AD  - Department of Anesthesiology, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Kim, Yong Chul
AU  - Kim YC
AD  - Department of Anesthesiology, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Park, Myoung Hee
AU  - Park MH
AD  - Department of Laboratory Medicine, Seoul National University College of Medicine, 
      Seoul, Korea. parkmhee@snu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20160725
PL  - Denmark
TA  - APMIS
JT  - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
JID - 8803400
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Herpesvirus 3, Human
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuralgia, Postherpetic/*genetics
MH  - Republic of Korea
MH  - Young Adult
OTO - NOTNLM
OT  - Postherpetic neuralgia
OT  - herpes zoster
OT  - human leukocyte antigen
EDAT- 2016/07/28 06:00
MHDA- 2017/02/01 06:00
CRDT- 2016/07/27 06:00
PHST- 2016/04/19 00:00 [received]
PHST- 2016/06/09 00:00 [accepted]
PHST- 2016/07/27 06:00 [entrez]
PHST- 2016/07/28 06:00 [pubmed]
PHST- 2017/02/01 06:00 [medline]
AID - 10.1111/apm.12575 [doi]
PST - ppublish
SO  - APMIS. 2016 Oct;124(10):865-71. doi: 10.1111/apm.12575. Epub 2016 Jul 25.