PMID- 27459097
OWN - NLM
STAT- MEDLINE
DCOM- 20170804
LR  - 20181202
IS  - 1399-3062 (Electronic)
IS  - 1398-2273 (Linking)
VI  - 18
IP  - 5
DP  - 2016 Oct
TI  - Viral load and ganciclovir (GCV) concentration in cerebrospinal fluid of patients 
      successfully treated with GCV or valGCV for human herpesvirus 6 
      encephalitis/myelitis following umbilical cord blood transplantation.
PG  - 773-776
LID - 10.1111/tid.12579 [doi]
AB  - We describe successful treatment of 3 cases of human herpesvirus 6 (HHV-6) 
      encephalitis/myelitis following cord blood transplantation (CBT). Ganciclovir 
      (GCV) (10 mg/kg/day) reduced HHV-6 load to undetectable levels in cerebrospinal 
      fluid (CSF). Early dose reduction in the presence of HHV-6 detectable in CSF 
      resulted in an increased HHV-6 load. GCV was capably shifted to valganciclovir 
      (VGCV) with an almost equivalent concentration. GCV/VGCV may be effective for 
      HHV-6 encephalitis/myelitis after CBT, although HHV-6 load in CSF should be 
      monitored.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Morita, D
AU  - Morita D
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Hirabayashi, K
AU  - Hirabayashi K
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Katsuyama, Y
AU  - Katsuyama Y
AD  - Department of Pharmacy, Shinshu University Hospital, Matsumoto, Japan.
FAU - Morokawa, H
AU  - Morokawa H
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Motobayashi, M
AU  - Motobayashi M
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Kurata, T
AU  - Kurata T
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Shigemura, T
AU  - Shigemura T
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Tanaka, M
AU  - Tanaka M
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Inaba, Y
AU  - Inaba Y
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Koike, K
AU  - Koike K
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Nakazawa, Y
AU  - Nakazawa Y
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan. yxnakaza@shinshu-u.ac.jp.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160907
PL  - Denmark
TA  - Transpl Infect Dis
JT  - Transplant infectious disease : an official journal of the Transplantation 
      Society
JID - 100883688
RN  - 0 (Antiviral Agents)
RN  - 0 (DNA, Viral)
RN  - 0 (Myeloablative Agonists)
RN  - GCU97FKN3R (Valganciclovir)
RN  - P9G3CKZ4P5 (Ganciclovir)
RN  - Human Herpesvirus 6 encephalitis
SB  - IM
MH  - Adult
MH  - Antiviral Agents/administration & dosage/*therapeutic use
MH  - Child, Preschool
MH  - DNA, Viral
MH  - Encephalitis, Viral/cerebrospinal fluid/*drug therapy/virology
MH  - Female
MH  - Fetal Blood
MH  - Ganciclovir/administration & dosage/analogs & derivatives/therapeutic use
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Humans
MH  - Male
MH  - Myelitis/cerebrospinal fluid/*drug therapy/virology
MH  - Myeloablative Agonists/adverse effects
MH  - Roseolovirus Infections/cerebrospinal fluid/*drug therapy/virology
MH  - Transplantation Conditioning/*adverse effects
MH  - Treatment Outcome
MH  - Valganciclovir
MH  - Viral Load/*drug effects
MH  - Young Adult
OTO - NOTNLM
OT  - HHV-6
OT  - cerebrospinal fluid
OT  - cord blood transplantation
OT  - encephalitis
OT  - ganciclovir
OT  - valganciclovir
EDAT- 2016/07/28 06:00
MHDA- 2017/08/05 06:00
CRDT- 2016/07/27 06:00
PHST- 2016/02/22 00:00 [received]
PHST- 2016/03/23 00:00 [revised]
PHST- 2016/05/10 00:00 [accepted]
PHST- 2016/07/28 06:00 [pubmed]
PHST- 2017/08/05 06:00 [medline]
PHST- 2016/07/27 06:00 [entrez]
AID - 10.1111/tid.12579 [doi]
PST - ppublish
SO  - Transpl Infect Dis. 2016 Oct;18(5):773-776. doi: 10.1111/tid.12579. Epub 2016 Sep 
      7.