PMID- 27459953
OWN - NLM
STAT- MEDLINE
DCOM- 20170525
LR  - 20180301
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 56
IP  - 11
DP  - 2016 Nov
TI  - Use of intravenous immunoglobulin in neonates at a tertiary academic hospital: a 
      retrospective 11-year study.
PG  - 2704-2711
LID - 10.1111/trf.13721 [doi]
AB  - BACKGROUND: Intravenous immunoglobulin (IVIG) is used to treat a variety of 
      diseases in the neonatal intensive care unit (NICU). Although audits have 
      reported on the spectrum of IVIG use in adults, the indications and utilization 
      in neonates has not been investigated. The objectives of this study were to 
      describe the usage pattern of and indications for IVIG in a tertiary care NICU. 
      STUDY DESIGN AND METHODS: A retrospective chart review was performed of all 
      neonates who received IVIG in the NICU from January 2003 to December 2013. Data 
      collected included patient demographic features, antenatal maternal details, 
      neonatal laboratory results, treatment details, adverse events, and patient 
      outcome. RESULTS: Thirty-seven neonates received IVIG over the 11-year period. 
      Twenty-three (67%) were treated for hemolytic disease of the newborn (HDN); 13 
      treatments were ABO related, six were anti-D related, and four were for 
      clinically significant antibodies. Fourteen (33%) were treated for non-HDN 
      causes, including eight for septic neonates, two for neonates with necrotizing 
      enterocolitis, two for neonates with a clinically significant antibody but 
      without evidence of hemolysis, and two for neonates with glucose 6-phosphate 
      dehydrogenase deficiency. A complete hemolytic workup was not performed 
      consistently before the receipt of IVIG. CONCLUSIONS: This novel assessment of 
      IVIG use in the NICU revealed the spectrum of disease for which IVIG is ordered. 
      This study also found that key diagnostic tests needed to confirm an immune 
      etiology for idiopathic jaundice are not performed routinely before IVIG receipt. 
      Neonatal transfusion-related databases are needed to carry out pragmatic clinical 
      trials to establish better evidence-based guidelines for IVIG therapy in the 
      NICU.
CI  - (c) 2016 AABB.
FAU - Lieberman, Lani
AU  - Lieberman L
AD  - Department of Clinical Pathology, University Health Network.
AD  - Department of Clinical Pathology, Sunnybrook Health Sciences Centre.
AD  - Department of Laboratory Medicine and Pathobiology, University of Toronto, 
      Toronto, Ontario, Canada.
AD  - Department of Newborn and Developmental Paediatrics, Sunnybrook Health Sciences 
      Centre, Toronto, ON, Canada.
FAU - Spradbrow, Jordan
AU  - Spradbrow J
AD  - Department of Clinical Pathology, Sunnybrook Health Sciences Centre.
FAU - Keir, Amy
AU  - Keir A
AD  - Robinson Research Institute, School of Medicine, University of Adelaide, South 
      Australia, Australia.
FAU - Dunn, Michael
AU  - Dunn M
AD  - Department of Newborn and Developmental Paediatrics, Sunnybrook Health Sciences 
      Centre, Toronto, ON, Canada.
FAU - Lin, Yulia
AU  - Lin Y
AD  - Department of Clinical Pathology, University Health Network.
AD  - Department of Clinical Pathology, Sunnybrook Health Sciences Centre.
AD  - Department of Laboratory Medicine and Pathobiology, University of Toronto, 
      Toronto, Ontario, Canada.
FAU - Callum, Jeannie
AU  - Callum J
AD  - Department of Clinical Pathology, University Health Network.
AD  - Department of Clinical Pathology, Sunnybrook Health Sciences Centre.
AD  - Department of Laboratory Medicine and Pathobiology, University of Toronto, 
      Toronto, Ontario, Canada.
LA  - eng
PT  - Journal Article
DEP - 20160726
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Enterocolitis, Necrotizing/drug therapy
MH  - Erythroblastosis, Fetal/drug therapy
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal
MH  - Jaundice, Neonatal/diagnosis/drug therapy
MH  - Male
MH  - Retrospective Studies
MH  - Sepsis/drug therapy
MH  - Tertiary Care Centers
EDAT- 2016/07/28 06:00
MHDA- 2017/05/26 06:00
CRDT- 2016/07/28 06:00
PHST- 2016/02/18 00:00 [received]
PHST- 2016/05/20 00:00 [revised]
PHST- 2016/05/31 00:00 [accepted]
PHST- 2016/07/28 06:00 [pubmed]
PHST- 2017/05/26 06:00 [medline]
PHST- 2016/07/28 06:00 [entrez]
AID - 10.1111/trf.13721 [doi]
PST - ppublish
SO  - Transfusion. 2016 Nov;56(11):2704-2711. doi: 10.1111/trf.13721. Epub 2016 Jul 26.